ArticleWorld journal of surgery2010
The effect of obstruction and perforation on colorectal cancer disease-free survival.
Article in World journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Determinants of emergency presentation in patients with colorectal cancer: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Emergency Diagnostic Phenotypes and Differential Survival in Colorectal Cancer: A Real-World Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Local and National Trends in Emergency Presentation of Colon and Rectal Cancer.Journal of surgical oncology · 2025Article
- Factors associated with postoperative recurrence in perforated colorectal cancer: unraveling the high recurrence rate of perforated colorectal cancer.World journal of surgical oncology · 2025Article
- Comparison of early and long-term clinical outcomes in obstructed proximal and distal colon cancers undergoing emergent surgery.Przeglad gastroenterologiczny · 2025Article
- Comparison of postoperative prognoses for resectable colorectal cancer with vs. without oncologic emergency using propensity score‑matched analyses: A single-center retrospective observational study.Oncology letters · 2024Article
- Review
- Decreased Positive Fecal Occult Blood Tests and Delayed Medical Presentation for Colorectal Cancer during the Initial COVID-19 Pandemic Period: A Single-center Experience.Journal of the anus, rectum and colon · 2024Article
- Emergency transanal total mesorectal excision for perforated rectal cancer: a two-case series.Surgical case reports · 2022Article
- Oncologic outcome of colon cancer with perforation and obstruction.BMC gastroenterology · 2022Article
- Prognostic Factors for Survival in Transverse Colon Cancers.Journal of gastrointestinal cancer · 2022Article
- Predictive factors for distant recurrence of colorectal cancer in patients after curative resection for stage I-III colorectal cancer in Australia.Langenbeck's archives of surgery · 2021Article
- A 77-Year-Old Man with a Pulse Granuloma of the Descending Colon Identified by Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) Imaging 19 Months Following Surgical Resection for Rectal Carcinoma.The American journal of case reports · 2021Article
- Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer.World journal of surgical oncology · 2021Article
- Prognostic impact of primary tumor location in Stage III colorectal cancer-right-sided colon versus left-sided colon versus rectum: a nationwide multicenter retrospective study.Journal of gastroenterology · 2020Article
- Article
- Emergency surgery for obstructing and perforated colon cancer: patterns of recurrence and prognostic factors.Techniques in coloproctology · 2019Observational
- Curative treatment for metastatic colorectal cancer in the young population: is it worth it?Journal of gastrointestinal oncology · 2019Article
- Outcome of colon cancer initially presenting as colon perforation and obstruction.World journal of surgical oncology · 2017Article
- Young colorectal cancer patients often present too late.International journal of colorectal disease · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstruction (OBSTR) and perforation (PERF) in colorectal cancer impact adversely upon outcomes, and cancer-related survival may also be affected. However, data are sparse, particularly on disease-free survival (DFS) where the cancer is both obstructed and perforated (OBS-PERF).
methodsData were extracted from a prospectively collected database of 1876 colorectal cancer patients managed and followed up at the Royal Brisbane Hospital from 1984 to 2004. The patients who had curative surgery (n = 1426) were classified as OBSTR (n = 153), PERF (n = 53), OBS-PERF (n = 19), and uncomplicated (UNCOM; n = 1201). Kaplan-Meier survival and Cox proportional hazard analyses were performed.
resultsPostoperative mortality within 30 days of surgery was 1.5% (n = 22) and the overall complication rate was 40.8% (n = 582). However, only 7.2% (n = 102) required reoperations. The median survival time was 71 (IQR = 64.9-77.1) months and the median follow-up for DFS was 37.5 (IQR 14-68) months. The overall recurrence rate was 32.7% (n = 466), the local recurrence rate was 9.4% (n = 135), and local and distant recurrences occurred in the same patient in 4.7% (n = 67). Male gender, OBSTR, PERF, OBS-PERF, emergency operation, major medical and surgical complications, reoperation, TNM staging, tumor grading, and tumor venous invasion adversely affected DFS (p < 0.05). Multivariate analysis showed that OBS-PERF (p = 0.008), major medical complications (p = 0.011), reoperation (p = 0.018), TNM staging (p < 0.001), grading (p = 0.018), and venous invasion (p = 0.002) were independently associated with a poorer DFS.
conclusionsOBS-PERF colorectal cancer is associated with a poorer DFS, which may be worse than either OBSTR or PERF alone.
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