ArticleWorld journal of surgery2010
Platelet transfusion can be related to liver regeneration after living donor liver transplantation.
Article in World journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Low viscoelastic clot strength, platelet transfusions, and graft dysfunction are associated with persistent postoperative ascites following liver transplantation.American journal of surgery · 2022Article
- Dualistic role of platelets in living donor liver transplantation: Are they harmful?World journal of gastroenterology · 2022Review
- Disease Mechanisms of Perioperative Organ Injury.Anesthesia and analgesia · 2020Review
- Platelet and liver regeneration after liver surgery.Surgery today · 2020Review
- Clinical Implications of Thrombocytopenia for the Cirrhotic Patient.Hepatic medicine : evidence and research · 2020Review
- Low platelet count: Predictor of death and graft loss after liver transplantation.World journal of hepatology · 2019Article
- Association Between Changes in Splanchnic Hemodynamics and Risk Factors of Portal Venous System Thrombosis After Splenectomy with Periesophagogastric Devascularization.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Thrombocytopenia after liver transplantation: Should we care?World journal of gastroenterology · 2018Review
- Splenectomy before adult liver transplantation: a retrospective study.BMC surgery · 2017Article
- Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure.World journal of gastroenterology · 2017Article
- Predictive Role of Intraoperative Plasma Fibrinogen for Postoperative Portal Venous Flow in Living Donor Liver Transplantation.Annals of transplantation · 2017Article
- Predictive factors of short term outcome after liver transplantation: A review.World journal of gastroenterology · 2016Review
- Immediate Postoperative Low Platelet Counts After Living Donor Liver Transplantation Predict Early Allograft Dysfunction.Medicine · 2015Article
- Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy.World journal of gastroenterology · 2014Observational
- Novel therapy for liver regeneration by increasing the number of platelets.Surgery today · 2013Review
- Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice.World journal of gastroenterology · 2013Article
- Splenectomy affects the balance between hepatic growth factor and transforming growth factor-β and its effect on liver regeneration is dependent on the amount of liver resection in rats.Journal of the Korean Surgical Society · 2012Article
- Intensive care management of liver transplanted patients.World journal of hepatology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough liver regeneration is a fundamental aspect of living donor liver transplantation (LDLT), the factors that affect liver regeneration during the early post-transplantation period have not been thoroughly investigated. Recently it was suggested that platelets contribute to liver regeneration. The aim of the present study was to identify the major factors that affect liver graft regeneration during the early post-transplantation period. MATERIALS AND
methodsEighty-seven right liver grafted, adult-to-adult LDLT patients were retrospectively analyzed. Liver regeneration was assessed by volumetry from computed tomographic (CT) scans obtained between the 9th and 11th postoperative days. The authors investigated relationships between clinical variables and liver graft regeneration rates, and they conducted multiple regression analysis on factors found to be significant by univariate analysis.
resultsMean graft weight at operation was 722.9 +/- 109.7 g, and mean graft volume assessed by follow-up CT was 1,042.2 +/- 155.6 ml, reflecting a mean liver graft regeneration of 45.9 +/- 22.3%. The graft regeneration was found to correlate inversely with graft-to-recipient weight ratio (GRWR, r = -0.406, p < 0.001) and directly with portal flow velocity (cm/s; r = 0.307; p = 0.004) and splenic index (cm(3); r = 0.282; p = 0.009). Moreover, the total amount (units) of platelets transfused was found to be significantly associated with graft regeneration (r = 0.293; p = -.006). Stepwise regression analysis showed that GRWR (beta = -33.124; p = 0.001), total amount of platelets transfused (beta = 0.771; p = 0.012), and splenic index (beta = -0.010; p = 0.049) were independently associated with graft regeneration.
conclusionsThe results of the present study suggest that platelets play a significant role in human liver regeneration after LDLT.
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