ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2007
Single-Molecule Studies on Fluorescently Labeled Silver Particles: Effects of Particle Size.
Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 109 citations in OpenAlex.
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- Metal-enhancement study of dual functional photosensitizers with aggregation-induced emission and singlet oxygen generation.Nanoscale advances · 2020Article
- Detection of Intracellular Gold Nanoparticles: An Overview.Materials (Basel, Switzerland) · 2018Review
- Metal-enhanced fluorescence of dye-doped silica nano particles.Journal of fluorescence · 2015Article
- Tamm State-Coupled Emission: Effect of Probe Location and Emission Wavelength.The journal of physical chemistry. C, Nanomaterials and interfaces · 2014Article
- First observation of enhanced luminescence from single lanthanide chelates on silver nanorods.Chemical communications (Cambridge, England) · 2014Article
- Radiative decay engineering 7: Tamm state-coupled emission using a hybrid plasmonic-photonic structure.Analytical biochemistry · 2014Article
- Luminescent Properties of Eu(III) Chelates on Metal Nanorods.The journal of physical chemistry. C, Nanomaterials and interfaces · 2013Article
- A straightforward immunoassay applicable to a wide range of antibodies based on surface enhanced fluorescence.Journal of fluorescence · 2013Article
- Fluorescence Intensity and Lifetime Cell Imaging with Luminescent Gold Nanoclusters.The journal of physical chemistry. C, Nanomaterials and interfaces · 2012Article
- Metal plasmon-coupled fluorescence imaging and label free coenzyme detection in cells.Biochemical and biophysical research communications · 2012Article
- Fluorescent metal nanoshell and CK19 detection on single cell image.Biochemical and biophysical research communications · 2011Article
- Direct observation of chemokine receptors 5 on T-lymphocyte cell surfaces using fluorescent metal nanoprobes 2: Approximation of CCR5 populations.Biochemical and biophysical research communications · 2011Article
- Direct observation to chemokine receptor 5 on T-lymphocyte cell surface using fluorescent metal nanoprobes.Biochemical and biophysical research communications · 2010Article
- Gold nanoparticles delivery in mammalian live cells: a critical review.Nano reviews · 2010Article
- Modification of single molecule fluorescence near metallic nanostructures.Laser & photonics reviews · 2009Article
- Fluorescent avidin-bound silver particle: a strategy for single target molecule detection on a cell membrane.Analytical chemistry · 2009Article
- Plasmon-controlled fluorescence towards high-sensitivity optical sensing.Advances in biochemical engineering/biotechnology · 2009Review
- Enhanced fluorescence images for labeled cells on silver island films.Langmuir : the ACS journal of surfaces and colloids · 2008Article
- Fluorescence lifetime correlation spectroscopic study of fluorophore-labeled silver nanoparticles.Analytical chemistry · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We studied the dependence of single-molecule fluorescence on the size of nearby metal particles. The silver particles were synthesized with average diameters of metal cores being 5, 20, 50, 70, and 100 nm, respectively. A single-stranded oligonucleotide was chemically bound to a single silver particle and a Cy5-labeled complementary single-stranded oligonucleotide was hybridized with the particle-bound oligonucleotide. The space between the fluorophore and metal core was separated by a rigid hybridized DNA duplex of 8 nm length. The single fluorescence images and intensity traces were recorded by scanning confocal microscopy. The single fluorophore-labeled 50 nm silver particles displayed the most enhanced intensity, a factor of 17-fold increase relative to the free fluorophores in the absence of metal. Numerical simulations by the finite-difference time-domain (FDTD) method and results from Mie theory were used to compare with the experimental results. The 50 nm silver particles were also labeled by multiple fluorophores. The fluorescence intensity of multiple fluorophore-labeled metal particles increases dramatically with the loading number and reached 400-fold relative to the free single fluorophore when the loading number of fluorophore per metal particle was 50. The fluorophore also displayed better photostability when binding on the metal particle. These results can aid us to develop novel nanoscale fluorophores for clinical diagnostics and bioassay.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.