ArticleJournal of biomedicine & biotechnology2010
Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs.Frontiers in immunology · 2023Review
- Immune System Investigation Using Parasitic Helminths.Annual review of immunology · 2021Review
- Mammalian Neuropeptides as Modulators of Microbial Infections: Their Dual Role in Defense versus Virulence and Pathogenesis.International journal of molecular sciences · 2021Review
- Neurokinin receptors and their implications in various autoimmune diseases.Current research in immunology · 2021Review
- Host immune responses during Taenia solium Neurocysticercosis infection and treatment.PLoS neglected tropical diseases · 2020Review
- Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P.Journal of neuroinflammation · 2017Article
- Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis.Journal of neuroinflammation · 2017Article
- The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders.Frontiers in cellular neuroscience · 2016Review
- Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis.BioMed research international · 2014Article
- Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways.Endocrinology · 2011Article
- Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.Annals of the New York Academy of Sciences · 2011Review
- What Causes Seizures in Neurocysticercosis?Epilepsy currentsReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cysticercosis is an infection with larval cysts of the cestode Taenia solium. Through pathways that are incompletely understood, dying parasites initiate a granulomatous reaction that, in the brain, causes seizures. Substance P (SP), a neuropeptide involved in pain-transmission, contributes to inflammation and previously was detected in granulomas associated with dead T. crassiceps cysts. To determine if SP contributes to granuloma formation, we measured granuloma-size and levels of IL-1beta, TNF-alpha, and IL-6 within granulomas in T. crassiceps-infected wild type (WT) mice and mice deficient in SP-precursor (SPP) or the SP-receptor (neurokinin 1, NK1). Granuloma volumes of infected SPP- and NK1-knockout mice were reduced by 31 and 36%, respectively, compared to WT mice (P < .05 for both) and produced up to 5-fold less IL-1beta, TNF-alpha, and IL-6 protein. Thus, SP signaling contributes to granuloma development and proinflammatory cytokine production in T. crassiceps infection and suggests a potential role for this mediator in human cystercercosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.