ReviewJournal of biomedicine & biotechnology2010
Synthetic biology: tools to design, build, and optimize cellular processes.
Review in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning.Science advances · 2025Article
- Microbial production of 5-Applied and environmental microbiology · 2024Article
- Synthetic Biology in Plants, a Boon for Coming Decades.Molecular biotechnology · 2021Review
- New Trends in Bioremediation Technologies Toward Environment-Friendly Society: A Mini-Review.Frontiers in bioengineering and biotechnology · 2021Review
- A set of synthetic versatile genetic control elements for the efficient expression of genes in Actinobacteria.Scientific reports · 2018Article
- Isolation of a non-genomic origin fluoroquinolone responsive regulatory element using a combinatorial bioengineering approach.Nucleic acids research · 2016Article
- Engineering the supply chain for protein production/secretion in yeasts and mammalian cells.Journal of industrial microbiology & biotechnology · 2015Review
- A condition-specific codon optimization approach for improved heterologous gene expression in Saccharomyces cerevisiae.BMC systems biology · 2014Article
- Engineered transcriptional systems for cyanobacterial biotechnology.Frontiers in bioengineering and biotechnology · 2014Review
- The development of synthetic biology: a patent analysis.Systems and synthetic biology · 2013Article
- Use of expression-enhancing terminators in Saccharomyces cerevisiae to increase mRNA half-life and improve gene expression control for metabolic engineering applications.Metabolic engineering · 2013Article
- Directed evolution as a powerful synthetic biology tool.Methods (San Diego, Calif.) · 2013Article
- Synthetic approaches to study transcriptional networks and noise in mammalian systems.IET systems biology · 2013Article
- Characterization of plasmid burden and copy number in Saccharomyces cerevisiae for optimization of metabolic engineering applications.FEMS yeast research · 2013Article
- Systems approaches for synthetic biology: a pathway toward mammalian design.Frontiers in physiology · 2013Article
- Generating in vivo cloning vectors for parallel cloning of large gene clusters by homologous recombination.PloS one · 2013Article
- Downward causation by information control in micro-organisms.Interface focus · 2012Article
- Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach.Applied and environmental microbiology · 2011Article
- DNA movies and panspermia.Life (Basel, Switzerland) · 2011Article
- Standard biological parts knowledgebase.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The general central dogma frames the emergent properties of life, which make biology both necessary and difficult to engineer. In a process engineering paradigm, each biological process stream and process unit is heavily influenced by regulatory interactions and interactions with the surrounding environment. Synthetic biology is developing the tools and methods that will increase control over these interactions, eventually resulting in an integrative synthetic biology that will allow ground-up cellular optimization. In this review, we attempt to contextualize the areas of synthetic biology into three tiers: (1) the process units and associated streams of the central dogma, (2) the intrinsic regulatory mechanisms, and (3) the extrinsic physical and chemical environment. Efforts at each of these three tiers attempt to control cellular systems and take advantage of emerging tools and approaches. Ultimately, it will be possible to integrate these approaches and realize the vision of integrative synthetic biology when cells are completely rewired for biotechnological goals. This review will highlight progress towards this goal as well as areas requiring further research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.