ArticleMediators of inflammation2009
Regulation of chemokine production via oxidative pathway in HeLa cells.
Article in Mediators of inflammation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Characterization and probiotic properties of3 Biotech · 2019Article
- Reactive oxygen species induce injury of the intestinal epithelium during hyperoxia.International journal of molecular medicine · 2018Article
- Influence of reactive oxygen species on secretory component in the intestinal epithelium during hyperoxia.Experimental and therapeutic medicine · 2017Article
- Retinal flavoprotein fluorescence correlates with mitochondrial stress, apoptosis, and chemokine expression.Experimental eye research · 2011Article
- Lymphocyte function antigen-1 regulates neutrophil recruitment and tissue damage in acute pancreatitis.British journal of pharmacology · 2011Article
- HPV16E6-dependent c-fos expression contributes to AP-1 complex formation in SiHa cells.Mediators of inflammation · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation is associated with disease progression and, by largely unknown mechanisms, has been said to drive oncogenesis. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal that includes proteinases, antimicrobial peptides, and ROS. Reactive oxygen species (ROSs) induce chemokines. In the present study, the concentrations of IL-8 in culture supernatants of HeLa cells treated with ROS were determined by enzyme-linked immunosorbent assay. We used o-phenanthroline to deplete Fe(2+) in order to investigate the mechanisms through which ROSs induce IL-8 secretion in our system. The iron chelator o-phenanthroline effectively inhibited H(2)O(2)-induced ERK2 activation. Enzyme-linked immunosorbent assays showed that IL-8 protein secretion was elevated in ROS-treated HeLa cells. When Fe(2+) was removed from these cells, IL-8 secretion was inhibited. Collectively, these results indicate that Fe(2+)-mediated Erk pathway activation is an important signal transduction pathway in ROS-induced IL-8 secretion in epithelial cells.
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Registered trials
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