ArticleThe EMBO journal2010
Force generated by actomyosin contraction builds bridges between adhesive contacts.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 112 citations in OpenAlex.
- Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction.Nature communications · 2025Article
- Advances in micropatterning technology for mechanotransduction research.Mechanobiology in medicine · 2024Review
- E-cadherin adhesion dynamics as revealed by an accelerated force ramp are dependent upon the presence of α-catenin.Biochemical and biophysical research communications · 2023Article
- Emergent collective organization of bone cells in complex curvature fields.Nature communications · 2023Article
- Curved Nanofiber Network Induces Cellular Bridge Formation to Promote Stem Cell Mechanotransduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Tether-guided lamellipodia enable rapid wound healing.Biophysical journal · 2022Article
- Cancer cells can be killed mechanically or with combinations of cytoskeletal inhibitors.Frontiers in pharmacology · 2022Review
- Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity.Integrative biology : quantitative biosciences from nano to macro · 2021Article
- Article
- Complementary mesoscale dynamics of spectrin and acto-myosin shape membrane territories during mechanoresponse.Nature communications · 2020Article
- Channeling Effect and Tissue Morphology in a Perfusion Bioreactor Imaged by X-Ray Microtomography.Tissue engineering and regenerative medicine · 2020Article
- Cellular Contact Guidance Emerges from Gap Avoidance.Cell reports. Physical science · 2020Article
- The Research Advance of Cell BridgesFrontiers in bioengineering and biotechnology · 2020Review
- A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing.Annual review of cell and developmental biology · 2019Review
- Cellular nanoscale stiffness patterns governed by intracellular forces.Nature materials · 2019Article
- Large and reversible myosin-dependent forces in rigidity sensing.Nature physics · 2019Article
- Large-scale curvature sensing by directional actin flow drives cellular migration mode switching.Nature physics · 2019Article
- Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts.Molecular biology of the cell · 2018Article
- Contact guidance persists under myosin inhibition due to the local alignment of adhesions and individual protrusions.Scientific reports · 2017Article
- Molecular stretching modulates mechanosensing pathways.Protein science : a publication of the Protein Society · 2017Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Extracellular matrices in vivo are heterogeneous structures containing gaps that cells bridge with an actomyosin network. To understand the basis of bridging, we plated cells on surfaces patterned with fibronectin (FN)-coated stripes separated by non-adhesive regions. Bridges developed large tensions where concave cell edges were anchored to FN by adhesion sites. Actomyosin complexes assembled near those sites (both actin and myosin filaments) and moved towards the centre of the non-adhesive regions in a treadmilling network. Inhibition of myosin-II (MII) or Rho-kinase collapsed bridges, whereas extension continued over adhesive areas. Inhibition of actin polymerization (latrunculin-A, jasplakinolide) also collapsed the actomyosin network. We suggest that MII has distinct functions at different bridge regions: (1) at the concave edges of bridges, MIIA force stimulates actin filament assembly at adhesions and (2) in the body of bridges, myosin cross-links actin filaments and stimulates actomyosin network healing when breaks occur. Both activities ensure turnover of actin networks needed to maintain stable bridges from one adhesive region to another.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.