ArticleJournal of acquired immune deficiency syndromes (1999)2010
The prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Uganda.
Article in Journal of acquired immune deficiency syndromes (1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of laboratory-confirmed Pneumocystis jirovecii in HIV-infected adults in Africa: A systematic review and meta-analysis.Medical mycology · 2021Pooled it
- Article
- A rare case of disseminated pulmonary cryptococcosis in an immunocompetent patient.BMC pulmonary medicine · 2024Article
- Cryptococcosis with pulmonary cavitation in an immunocompetent child: a case report and literature review.BMC infectious diseases · 2024Review
- A Longitudinal Study of Multimodal Bronchoscopy Training in Uganda.ATS scholar · 2023Article
- Clinical Diagnosis, Treatment, and Laboratory Detection of 50 Cases of Pulmonary Cryptococcosis.Computational and mathematical methods in medicine · 2022Article
- Evaluation of antibody responses to panels of M. tuberculosis antigens as a screening tool for active tuberculosis in Uganda.PloS one · 2017Article
- Pulmonary cryptococcosis presenting as acute severe respiratory distress in a newly diagnosed HIV patient in Tanzania: a case report.Clinical case reports · 2015Article
- Increased monocyte turnover is associated with interstitial macrophage accumulation and pulmonary tissue damage in SIV-infected rhesus macaques.Journal of leukocyte biology · 2015Article
- Gastrointestinal cryptococcoma - Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?Medical mycology case reports · 2015Article
- Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections.Respirology (Carlton, Vic.) · 2014Article
- Prevalence and outcomes of cryptococcal antigenemia in HIV-seropositive patients hospitalized for suspected tuberculosis in Uganda.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- New Insights into HIV/AIDS-Associated Cryptococcosis.ISRN AIDS · 2013Review
- CrAg lateral flow assay for cryptococcosis.Expert opinion on medical diagnostics · 2012Article
- Pulmonary coinfection by Pneumocystis jiroveci and Cryptococcus neoformans.Asian Pacific journal of tropical biomedicine · 2012Article
- Article
- Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms.PloS one · 2012Article
- Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study.PloS one · 2011Article
- Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study.PLoS medicine · 2010Article
Corrections and comments
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8 authors.
Funding
Abstract
backgroundThe prevalence and clinical course of pulmonary cryptococcosis in Sub-Saharan Africa are not well described.
methodsConsecutive HIV-infected adults hospitalized at Mulago Hospital (Kampala, Uganda) between September 2007 and July 2008 with cough >or=2 weeks were enrolled. Patients with negative sputum smears for acid-fast bacilli were referred for bronchoscopy with bronchoalveolar lavage (BAL). BAL fluid was examined for mycobacteria, Pneumocystis jirovecii, and fungi. Patients were followed 2 and 6 months after hospital discharge.
resultsOf 407 patients enrolled, 132 (32%) underwent bronchoscopy. Of 132 BAL fungal cultures, 15 (11%) grew Cryptococcus neoformans. None of the patients were suspected to have pulmonary cryptococcosis on admission. The median CD4 count among those with pulmonary cryptococcosis was 23 cells per microliter (interquartile range = 7-51). Of 13 patients who completed 6-month follow-up, 4 died and 9 were improved, including 5 who had started antiretroviral therapy but had not received antifungal medication.
conclusionsPulmonary cryptococcosis is common in HIV-infected tuberculosis suspects in Uganda. Early initiation of antiretroviral therapy in those with isolated pulmonary infection may improve outcomes, even without antifungal therapy. This finding suggests that some HIV-infected patients with C. neoformans isolated from respiratory samples may have colonization or localized infection.
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