Evidence map›Paper›PMID 20150766›Full record

ReviewmAbs

Antibody immunosuppressive therapy in solid-organ transplant: Part I.

Nadim Mahmud, Dusko Klipa, Nasimul Ahsan

Abstract readReview
In one paragraph

Review in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Immunosuppressants/Immunomodulators and Malignancy.Journal of clinical medicine · 2025
    Review
  5. Review
  6. Review
  7. A Comprehensive Landscape ofTransplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  8. Novel Immunosuppression in Solid Organ Transplantation.Handbook of experimental pharmacology · 2022
    Article
  9. Article
  10. Article
  11. Osteopontin and Transplantation: Where Are We Now?Archivum immunologiae et therapiae experimentalis · 2021
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nadim MahmudStanford School of Medicine, Palo Alto, CA, USA.
Dusko Klipa
Nasimul Ahsan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, a wide variety of both polyclonal and monoclonal antibodies are being routinely utilized to prevent and treat solid organ rejection. More commonly, these agents are also administered in order to delay introduction of calcineurin inhibitors, especially in patients with already compromised renal function. While these antibody therapies dramatically reduced the incidence of acute rejection episodes and improved both short and long-term graft survival, they are also associated with an increased incidence of opportunistic infections and neoplastic complications. Therefore, effective patient management must necessarily balance these risks against the potential benefits of the therapy.

Indexed as

Immunosuppression TherapyImmunotherapyOrgan TransplantationAnimalsAntibodies, MonoclonalGraft RejectionHumansMonitoring, PhysiologicNeoplasmsOpportunistic InfectionsAntibodies, Monoclonal

Identifiers

PMID20150766
PMCPMC2840233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.