ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Speeding of VO2 kinetics with endurance training in old and young men is associated with improved matching of local O2 delivery to muscle O2 utilization.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03043469 (Dysfunctional Breathing), which is not on this map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dysfunctional Breathing: Multidimensional Characterisation and Assessment Tool
Who cites it
68 citing papers in PubMed.
- Trial
- Exercise training-induced speeding ofEuropean journal of applied physiology · 2025Trial
- Aerobic capacity andEuropean journal of applied physiology · 2023Trial
- Cocoa-flavanols enhance moderate-intensity pulmonaryEuropean journal of applied physiology · 2021Trial
- Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Trial
- Are the parameters of VO2, heart rate and muscle deoxygenation kinetics affected by serial moderate-intensity exercise transitions in a single day?European journal of applied physiology · 2011Trial
- Speeding of VO2 kinetics in response to endurance-training in older and young women.European journal of applied physiology · 2011Trial
- Faster oxygen uptake kinetics during recovery is related to better repeated sprinting ability.European journal of applied physiology · 2010Trial
- Near-Infrared Spectroscopy in the Pathophysiology, Diagnosis, and Exercise-Based Management of Muscle Oxygenation Impairment.Diagnostics (Basel, Switzerland) · 2026Review
- Effects of reducing sedentary behaviour on cardiovascular health, skeletal muscle oxidative capacity and functional exercise capacity in sedentary adults: a randomised controlled trial.BMJ open sport & exercise medicine · 2026Article
- VOLupus · 2025Article
- Quantifying altered oxygen kinetics and reducing metabolic test times for children with cerebral palsy: a dual-exponential Bayesian modeling approach.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Assessing Aerobic and Anaerobic Thresholds with Emphasis on Isocapnic Buffering in Endurance Runners.International journal of exercise science · 2025Article
- Leg cycling efficiency is unaltered in healthy aging regardless of sex or training status.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- No sex differences in oxygen uptake or extraction kinetics in the moderate or heavy exercise intensity domains.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The effects of endurance training on muscle oxygen desaturation during incremental exercise tests: a systematic review and meta-analysis.Frontiers in sports and active living · 2024Article
- Acute Oxygen Consumption Response to Fast Start High-Intensity Intermittent Exercise.Sports (Basel, Switzerland) · 2023Article
- Adaptations to 4 weeks of high-intensity interval training in healthy adults with different training backgrounds.European journal of applied physiology · 2023Article
- How Priming Exercise Affects Oxygen Uptake Kinetics: From Underpinning Mechanisms to Endurance Performance.Sports medicine (Auckland, N.Z.) · 2023Review
- Longitudinal alterations of pulmonaryFrontiers in sports and active living · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The time course and mechanisms of adjustment of pulmonary oxygen uptake (V(O(2))) kinetics (time constant tauV(O(2p))) were examined during step transitions from 20 W to moderate-intensity cycling in eight older men (O; 68 +/- 7 yr) and eight young men (Y; 23 +/- 5 yr) before training and at 3, 6, 9, and 12 wk of endurance training. V(O(2p)) was measured breath by breath with a volume turbine and a mass spectrometer. Changes in deoxygenated hemoglobin concentration (Delta[HHb]) were measured by near-infrared spectroscopy. V(O(2p)) and Delta[HHb] were modeled with a monoexponential model. Training was performed on a cycle ergometer three times per week for 45 min at approximately 70% of peak V(O(2)). Pretraining tauV(O(2p)) was greater (P < 0.05) in O (43 +/- 10 s) than Y (34 +/- 8 s). tauV(O(2p)) decreased (P < 0.05) by 3 wk of training in both O (35 +/- 9 s) and Y (22 +/- 8 s), with no further changes thereafter. The pretraining overall adjustment of Delta[HHb] was faster than tauV(O(2p)) in both O and Y, resulting in Delta[HHb]/V(O(2p)) displaying an "overshoot" during the transient relative to the subsequent steady-state level. After 3 wk of training the Delta[HHb]/V(O(2p)) overshoot was attenuated in both O and Y. With further training, this overshoot persisted in O but was eliminated after 6 wk in Y. The training-induced speeding of V(O(2p)) kinetics in O and Y at 3 wk of training was associated with an improved matching of local O(2) delivery to muscle V(O(2)) (as represented by a lower Delta[HHb]/V(O(2p))). The continued overshoot in Delta[HHb]/V(O(2p)) in O may reflect a reduced vasodilatory responsiveness that may limit muscle blood flow distribution during the on-transient of exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.