ArticleThe Journal of biological chemistry2010
Sekiguchi lesion gene encodes a cytochrome P450 monooxygenase that catalyzes conversion of tryptamine to serotonin in rice.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93 citing papers in PubMed, 247 citations in OpenAlex.
- Exploring the role of serotonin as a plant stress modulator.Plant signaling & behavior · 2026Review
- OsASA2 Loss-of-Function Confers Broad-Spectrum Disease Resistance and Triggers Cell Death by Regulating Anthranilate Synthase Activity in Rice.Molecular plant pathology · 2026Article
- Biosynthesis of pathogen-induced hydroxylated tryptamine derivatives in barley.Plant physiology · 2026Article
- OsMYB306-OsRAV11 Regulates Resistance of Rice to Striped Stem Borer by Modulating Serotonin Biosynthesis.Plant biotechnology journal · 2026Article
- From Abiotic Stress to Emerging Environmental Pollutants: Expanding Roles of Melatonin and NO in Plant Defense.International journal of molecular sciences · 2026Review
- Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds.Stress biology · 2026Article
- Identification and Regulation of Melatonin Biosynthetic Genes in Sweet Pepper During Ripening and Melatonin Treatment.Antioxidants (Basel, Switzerland) · 2026Article
- Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants.Science advances · 2026Article
- Transcriptomic and metabolomic analyses revealFrontiers in plant science · 2026Article
- Engineering hormonal crosstalk to enhance serotonin/melatonin levels in rice.Nature communications · 2025Article
- Decreased Expression of a Phosphoribosylanthranilate Transferase-Encoding Gene,International journal of molecular sciences · 2025Article
- Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses.Plant communications · 2025Review
- Lesion Mimic Mutant: An Ideal Genetic Material for Deciphering the Balance Between Plant Immunity and Growth.Rice (New York, N.Y.) · 2025Review
- Rice Cytochrome P450 Protein CYP71P1 Is Required for Heat Stress Tolerance by Regulating Serotonin Biosynthesis and ROS Homeostasis.Plants (Basel, Switzerland) · 2025Article
- Comparative transcriptome and genome analysis between susceptible Zhefang rice variety Diantun 502 and its resistance variety Diantun 506 upon Magnaporthe oryzae infection.BMC plant biology · 2025Article
- Multi-Omics Analysis Reveals That AhNHL Contributes to Melatonin-Mediated Cadmium Tolerance in Peanut Plants.Journal of pineal research · 2025Article
- Serotonin Mitigates ColdStress-Induced Damage inInternational journal of molecular sciences · 2025Article
- Biosynthetic Origin of the Methoxy Group in Quinine and Related Alkaloids.Angewandte Chemie (International ed. in English) · 2025Article
- On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (Plants (Basel, Switzerland) · 2025Article
- Differential Stress Responses to Rice Blast Fungal Infection Associated with the Vegetative Growth Phase in Rice.Plants (Basel, Switzerland) · 2025Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin is a well known neurotransmitter in mammals and plays an important role in various mental functions in humans. In plants, the serotonin biosynthesis pathway and its function are not well understood. The rice sekiguchi lesion (sl) mutants accumulate tryptamine, a candidate substrate for serotonin biosynthesis. We isolated the SL gene by map-based cloning and found that it encodes CYP71P1 in a cytochrome P450 monooxygenase family. A recombinant SL protein exhibited tryptamine 5-hydroxylase enzyme activity and catalyzed the conversion of tryptamine to serotonin. This pathway is novel and has not been reported in mammals. Expression of SL was induced by the N-acetylchitooligosaccharide (chitin) elicitor and by infection with Magnaporthe grisea, a causal agent for rice blast disease. Exogenously applied serotonin induced defense gene expression and cell death in rice suspension cultures and increased resistance to rice blast infection in plants. We also found that serotonin-induced defense gene expression is mediated by the RacGTPase pathway and by the G alpha subunit of the heterotrimeric G protein. These results suggest that serotonin plays an important role in rice innate immunity.
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