ArticleSocial cognitive and affective neuroscience2010
Amygdala volume correlates positively with fearfulness in normal healthy girls.
Article in Social cognitive and affective neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.Molecular psychiatry · 2026Pooled it
- The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis.Progress in neurobiology · 2015Pooled it
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development.Cureus · 2025Review
- Behavioral moderators ofFrontiers in psychiatry · 2025Article
- Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels.Psychological medicine · 2023Article
- The Association Between Maternal Cortisol and Infant Amygdala Volume Is Moderated by Socioeconomic Status.Biological psychiatry global open science · 2023Article
- Postnatal maternal distress, infant subcortical brain macrostructure and emotional regulation.Psychiatry research. Neuroimaging · 2023Article
- Association of Amygdala Development With Different Forms of Anxiety in Autism Spectrum Disorder.Biological psychiatry · 2022Article
- Dispositional Negative Emotionality in Childhood and Adolescence Predicts Structural Variation in the Amygdala and Caudal Anterior Cingulate During Early Adulthood: Theoretically and Empirically Based Tests.Research on child and adolescent psychopathology · 2021Article
- Amygdala subnuclei development in adolescents with autism spectrum disorder: Association with social communication and repetitive behaviors.Brain and behavior · 2021Article
- Material hardship, prefrontal cortex-amygdala structure, and internalizing symptoms in children.Developmental psychobiology · 2021Article
- Brain structure correlates of expected social threat and reward.Scientific reports · 2020Article
- Different brain profiles in children with prenatal alcohol exposure with or without early adverse exposures.Human brain mapping · 2020Article
- Orbitofrontal cortex grey matter volume is related to children's depressive symptoms.NeuroImage. Clinical · 2020Article
- Concordance of genetic variation that increases risk for anxiety disorders and posttraumatic stress disorders and that influences their underlying neurocircuitry.Journal of affective disorders · 2019Article
- Article
- Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety.Journal of autism and developmental disorders · 2017Article
- Widespread Volumetric Brain Changes following Tooth Loss in Female Mice.Frontiers in neuroanatomy · 2016Article
- Left hippocampus-amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals.Brain and behavior · 2015Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Research into the neural underpinnings of fear and fear-related pathology has highlighted the role of the amygdala. For instance, bilateral damage to the amygdaloid complex is associated with decreased appreciation of danger and recognition of fear in humans, whereas enlarged amygdala volume is associated with internalizing syndromes. It is unknown whether amygdala volume and fearfulness are related in the absence of pathology. We examined the correlation between normal fearfulness and amygdala morphology in 116 healthy children and adolescents (60 boys, 56 girls, age 7-17 years). Fearfulness was measured using the parent ratings on the Pediatric Behavior Scale and amygdala volumes were determined by manual tracing. We found a positive correlation between right amygdala volume in girls (r = 0.29). This relationship was more robust and present bilaterally when analyses were limited to girls with a positive nuclear family history of depression (for left r = 0.63; for right r = 0.58). In boys there was no significant relationship which may suggest that biological mechanisms differ between sexes. Given the role of enlarged amygdala volume in pathology, these findings may indicate that variation in amygdala morphology marks susceptibility to internalizing disorders.
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