ArticleDevelopment (Cambridge, England)2010
Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Evaluation of serum levels in children with delayed eruption.BMC oral health · 2024Article
- PTH1-34 promotes osteoblast formation through Beclin1-dependent autophagic activation.Journal of bone and mineral metabolism · 2021Article
- CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes.Molecular medicine reports · 2021Article
- CaSR as a Therapeutic Target and Tool in Human Dental Pulp: A Concise Review and Novel Hypothesis.Oral health & preventive dentistry · 2020Review
- GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1.Cell death and differentiation · 2018Article
- Mechanical constraint from growing jaw facilitates mammalian dental diversity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Exogenous PTHrP Repairs the Damaged Fracture Healing of PTHrP+/- Mice and Accelerates Fracture Healing of Wild Mice.International journal of molecular sciences · 2017Article
- Atypical skeletal manifestations of rickets in a familial hypocalciuric hypercalcemia patient.Bone research · 2017Article
- CBX7 deficiency plays a positive role in dentin and alveolar bone development.Journal of molecular histology · 2016Article
- The calcium-sensing receptor in bone metabolism: from bench to bedside and back.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Review
- The calcium-sensing receptor in bone--mechanistic and therapeutic insights.Nature reviews. Endocrinology · 2015Review
- Recombinant human parathyroid hormone related protein 1-34 and 1-84 and their roles in osteoporosis treatment.PloS one · 2014Article
- Calcium sensing receptor absence delays postnatal brain development via direct and indirect mechanisms.Molecular neurobiology · 2013Article
- The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice.American journal of physiology. Endocrinology and metabolism · 2012Article
- The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Endogenous PTH deficiency impairs fracture healing and impedes the fracture-healing efficacy of exogenous PTH(1-34).PloS one · 2011Article
- An improved transplantation strategy for mouse mesenchymal stem cells in an acute myocardial infarction model.PloS one · 2011Article
- Calcium and bone disease.BioFactors (Oxford, England)Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
To determine whether the calcium-sensing receptor (CaR) participates in tooth formation and dental alveolar bone development in mandibles in vivo, we examined these processes, as well as mineralization, in 2-week-old CaR-knockout (CaR(-/-)) mice. We also attempted to rescue the phenotype of CaR(-/-) mice by genetic means, in mice doubly homozygous for CaR and 25-hydroxyvitamin D 1alpha-hydroxylase [1alpha(OH)ase] or parathyroid hormone (Pth). In CaR(-/-) mice, which exhibited hypercalcemia, hypophosphatemia and increased serum PTH, the volumes of teeth and of dental alveolar bone were decreased dramatically, whereas the ratio of the area of predentin to total dentin and the number and surface of osteoblasts in dental alveolar bone were increased significantly, as compared with wild-type littermates. The normocalcemia present in CaR(-/-);1alpha(OH)ase(-/-) mice only slightly improved the defects in dental and alveolar bone formation observed in the hypercalcemic CaR(-/-) mice. However, these defects were completely rescued by the additional elimination of hypophosphatemia and by an increase in parathyroid hormone-related protein (PTHrP) expression in the apical pulp, Hertwig's epithelial root sheath and mandibular tissue in CaR(-/-); Pth(-/-) mice. Therefore, alterations in calcium, phosphorus and PTHrP contribute to defects in the formation of teeth and alveolar bone in CaR-deficient mice. This study indicates that CaR participates in the formation of teeth and in the development of dental alveolar bone in mandibles in vivo, although it appears to do so largely indirectly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.