SynthesisClinical immunology (Orlando, Fla.)2010
Good's syndrome remains a mystery after 55 years: A systematic review of the scientific evidence.
Synthesis in Clinical immunology (Orlando, Fla.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 2 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- When the Good Syndrome Goes Bad: A Systematic Literature Review.Frontiers in immunology · 2021Pooled it
- Characteristics of Good's Syndrome in China: A Systematic Review.Chinese medical journal · 2017Pooled it
- The use of pembrolizumab in a patient with progressive multifocal leukoencephalopathy associated with Good's syndrome: a case report.Acta neurologica Belgica · 2026Article
- Clinical characteristics and risk factors of cytomegalovirus infection in patients with good syndrome.BMC immunology · 2026Article
- Immunopathological Profile of Patients with Thymic Epithelial Tumour and Good Syndrome in Advanced Stage.Journal of clinical immunology · 2026Article
- Immunological spectrum in patients with thymoma: beyond good syndrome.Immunologic research · 2026Article
- Good Syndrome Presenting With Pulmonary Abnormalities Four Years After Thymectomy.Respirology case reports · 2026Article
- Proxy immunization enabling yellow fever vaccination after thymectomy.NPJ vaccines · 2026Article
- Oligoclonal expansion of atypical Vδ2Nature communications · 2026Article
- Article
- Recurrent invasive fungal infection with locally advanced thymoma: diagnostic challenges in complex mediastinal disease.Breathe (Sheffield, England) · 2026Article
- Perioperative Management of a Patient with Good Syndrome and Pancytopenia Undergoing Sternotomy and Thymectomy.Annals of cardiac anaesthesia · 2026Article
- When Central Tolerance Fails: Thymic Malignancies at the Intersection of Cancer Immunity and Autoimmunity.Cancers · 2026Review
- Navigating coexisting autoimmunity and immunodeficiency in thymoma: a case report of TAMA, Good's syndrome, and myasthenic crisis.Frontiers in immunology · 2026Article
- Article
- Good's syndrome and infections in a large retrospective cohort of thymoma.Frontiers in immunology · 2026Article
- Significant decreased CXCR3Frontiers in immunology · 2026Article
- CD19, immunoglobulin level, and varied anti-cytokine autoantibodies underline dichotomous susceptibility to types of infection in patients with thymomas.Frontiers in immunology · 2026Article
- Gastrointestinal pathology in Good's syndrome, thinking beyond common variable immunodeficiency: a clinicopathological observation.Virchows Archiv : an international journal of pathology · 2025Article
- Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Good syndrome (GS) is a rare association of thymoma and immunodeficiency first described more than 50 years ago. However, this syndrome still remains a mystery to clinicians. We systematically reviewed all the clinical, laboratory and immunologic findings from 152 patients with Good syndrome. The syndrome has a worldwide distribution and approximately half of the cases (47%) have been described in Europe. The diagnosis of thymoma preceded the diagnosis of hypogammaglobulinemia, infection, or diarrhea in 42% of patients whereas in 38% of patients the diagnoses were made almost simultaneously within 2 months of each other. We found significant mortality in patients with this syndrome (44.5%). Astute clinical acumen and increased awareness about the clinical and immunological profile of this syndrome may increase early recognition of this syndrome and prevent mortality. Further studies are needed to elucidate this clinical entity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.