ReviewCurrent opinion in microbiology2010
Use of two-component signal transduction systems in the construction of synthetic genetic networks.
Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- An Evolutionary Paradigm Favoring Cross Talk between Bacterial Two-Component Signaling Systems.mSystems · 2022Article
- Widespread Arginine Phosphorylation in Staphylococcus aureus.Molecular & cellular proteomics : MCP · 2022Article
- Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis.PLoS pathogens · 2020Article
- Modulation of Response Regulator CheY Reaction Kinetics by Two Variable Residues That Affect Conformation.Journal of bacteriology · 2020Article
- Identification and Characterization of the Two-Component System HK8700-RR8701 of Kocuria rhizophila DC2201.The protein journal · 2019Article
- Biofuel metabolic engineering with biosensors.Current opinion in chemical biology · 2016Review
- Genetic switches and related tools for controlling gene expression and electrical outputs of Geobacter sulfurreducens.Journal of industrial microbiology & biotechnology · 2016Article
- Transcription factor-based biosensors enlightened by the analyte.Frontiers in microbiology · 2015Review
- Phosphate sink containing two-component signaling systems as tunable threshold devices.PLoS computational biology · 2014Article
- Reciprocal regulation as a source of ultrasensitivity in two-component systems with a bifunctional sensor kinase.PLoS computational biology · 2014Article
- Foundations for the design and implementation of synthetic genetic circuits.Nature reviews. Genetics · 2012Review
- An asymmetry-to-symmetry switch in signal transmission by the histidine kinase receptor for TMAO.Structure (London, England : 1993) · 2012Article
- Different evolutionary modifications as a guide to rewire two-component systems.Bioinformatics and biology insights · 2012Article
- Bacterial phosphoproteomic analysis reveals the correlation between protein phosphorylation and bacterial pathogenicity.Genomics, proteomics & bioinformatics · 2011Review
- Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.Applied microbiology and biotechnology · 2010Review
- Protein histidine kinases: assembly of active sites and their regulation in signaling pathways.Current opinion in microbiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Two-component signal transduction systems are a common type of signaling system in prokaryotes; the typical cell has dozens of systems regulating aspects of physiology and controlling responses to environmental conditions. In this review, I consider how these systems may be useful for engineering novel cell functions. Examples of successful incorporation of two-component systems into engineered systems are noted, and features of the systems that favor or hinder potential future use of these signaling systems for synthetic biology applications are discussed. The focus will be on the engineering of novel couplings of sensory functions to signaling outputs. Recent successes in this area are noted, such as the development of light-sensitive transmitter proteins and chemotactic receptors responsive to nitrate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.