ArticleBiological psychiatry2010
N-methyl-D-aspartic acid receptors on striatal neurons are essential for cocaine cue reactivity in mice.
Article in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Stimulant Use, HIV, and Plasma Metabolites Among Men.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex.Frontiers in pharmacology · 2022Article
- Do specific NMDA receptor subunits act as gateways for addictive behaviors?Genes, brain, and behavior · 2017Review
- Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Utility of genetically modified mice for understanding the neurobiology of substance use disorders.Human genetics · 2012Review
- Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Article
- Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Review
- D-cycloserine facilitates extinction of cocaine self-administration in C57 mice.Synapse (New York, N.Y.) · 2011Article
- Unraveling the differential functions and regulation of striatal neuron sub-populations in motor control, reward, and motivational processes.Frontiers in behavioral neuroscience · 2011Article
- Emergence of dormant conditioned incentive approach by conditioned withdrawal in nicotine addiction.Biological psychiatry · 2010Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEnvironmental cues associated with cocaine evoke craving and seeking. This process, termed cue reactivity, is a critical element of cocaine addiction. Although glutamatergic neurotransmission has been implicated in this effect of cocaine, the precise subtype and localization in the brain of the glutamatergic receptor critical for cocaine cue reactivity is not well-understood.
methodsWe used a conditional N-methyl-D-aspartic acid receptor (NMDAR) knockout mouse whose NMDAR gene was deleted by Cre expression restricted to striatal neurons. To evaluate the role of NMDAR in cocaine cue reactivity, conditional knockout mice and control mice (n = 5-8/group) were conditioned for place preference with cocaine (5 and 10 mg/kg SC) for 3 days. Their subsequent place preference was examined in a drug-free state.
resultsAlthough control mice developed cocaine conditioned place preference, mice deficient for NMDAR on striatal neurons failed to develop conditioned place preference.
conclusionsThe NMDAR on striatal neurons is essential for the development of cocaine cue reactivity in the place conditioning paradigm. Our finding identifies a brain region whose constitutive NMDAR level serves as a determinant for susceptibility to this aspect of cocaine addiction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.