ArticleAmerican journal of ophthalmology2010
Incidence, ocular manifestations, and survival in children with neuroblastoma: a population-based study.
Article in American journal of ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
- Incidence and clinical characteristics of pediatric ocular tumors in a Midwestern US population.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023Article
- Article
- Incidence of Horner syndrome associated with neuroblastic disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass.Case reports in medicine · 2021Article
- LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Article
- Urine catecholamine levels as diagnostic markers for neuroblastoma in a defined population: implications for ophthalmic practice.Eye (London, England) · 2010Article
- 'Raccoon eyes' revisited.Pediatric radiology · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine the incidence, ophthalmic manifestations, and survival among children with neuroblastoma in a defined population.
designPopulation-based retrospective cohort.
methodsThe medical records of all pediatric (<19 years) residents of Olmsted County, Minnesota, diagnosed with neuroblastoma from January 1, 1969, through December 31, 2008, were retrospectively reviewed.
resultsFourteen children were diagnosed with neuroblastoma as residents of Olmstead County, Minnesota, during the 40-year period, yielding an age- and gender-adjusted incidence of 11.8 (95% confidence interval [CI]: 5.6-18.0) per million patients <15 years of age. The calculated incidence for patients presenting before the age of 5 in this cohort was 1 in 5970 children (95% CI: 3920-12 580 children). The mean age at diagnosis for the 14 study patients was 22.5 months (range, 10.4-42.6 months). Six of the 14 (43%; 95% CI: 18%-71%) had ocular manifestations, including orbital metastasis in 6 (100%), proptosis and ecchymosis in 4 (67%), ptosis in 2 (33%), and strabismus in 1 (17%). The Kaplan-Meier rate of survival for all 14 children was 57% at 1 year (95% CI: 36%-90%) and 50% at 5 years (95% CI: 30%-84%), while the 6 with eye findings had a survival rate of 17% at 9 months (95% CI: 3%-100%).
conclusionsThe incidence of neuroblastoma in this population was 11.8 per million patients <15 years, with ophthalmic involvement observed in 6 of the 14 study patients (43%). Orbital metastasis in the 6 children in this cohort was associated with poor prognosis.
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