ArticleJournal of biology2010
Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila.
Article in Journal of biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Novel Insights into TSC22D Family Genes in Metabolic Diseases and Cancer.Biomolecules · 2026Review
- Kinase interaction analysis predicts actions of the WNK-OSR1/SPAK pathway.Communications biology · 2025Article
- NRBP1 and TSC22D proteins affect distal convoluted tubule physiology through modulation of the WNK pathway.Science advances · 2025Article
- NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.Science advances · 2025Article
- Alternative splicing of bunched confers a dual role in hippo pathway-dependent growth and tumorigenesis.Oncogene · 2025Article
- NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway.bioRxiv : the preprint server for biology · 2024Article
- High NRBP1 expression promotes proliferation and correlates with poor prognosis in bladder cancer.Journal of Cancer · 2019Article
- Nuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer.Cell death & disease · 2018Article
- Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis.Nature communications · 2016Article
- Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila.Stem cell reviews and reports · 2015Article
- Hepatic transforming growth factor-β 1 stimulated clone-22 D1 controls systemic cholesterol metabolism.Molecular metabolism · 2014Article
- TSC22D4 is a molecular output of hepatic wasting metabolism.EMBO molecular medicine · 2013Article
- The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.PLoS genetics · 2013Article
- Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.The EMBO journal · 2012Article
- Identification and characterization of genes required for compensatory growth in Drosophila.Genetics · 2011Article
- Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.The EMBO journal · 2011Article
- Bunched and Madm: a novel growth-regulatory complex?Journal of biology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe TSC-22 domain family (TSC22DF) consists of putative transcription factors harboring a DNA-binding TSC-box and an adjacent leucine zipper at their carboxyl termini. Both short and long TSC22DF isoforms are conserved from flies to humans. Whereas the short isoforms include the tumor suppressor TSC-22 (Transforming growth factor-beta1 stimulated clone-22), the long isoforms are largely uncharacterized. In Drosophila, the long isoform Bunched A (BunA) acts as a growth promoter, but how BunA controls growth has remained obscure.
resultsIn order to test for functional conservation among TSC22DF members, we expressed the human TSC22DF proteins in the fly and found that all long isoforms can replace BunA function. Furthermore, we combined a proteomics-based approach with a genetic screen to identify proteins that interact with BunA. Madm (Mlf1 adapter molecule) physically associates with BunA via a conserved motif that is only contained in long TSC22DF proteins. Moreover, Drosophila Madm acts as a growth-promoting gene that displays growth phenotypes strikingly similar to bunA phenotypes. When overexpressed, Madm and BunA synergize to increase organ growth.
conclusionsThe growth-promoting potential of long TSC22DF proteins is evolutionarily conserved. Furthermore, we provide biochemical and genetic evidence for a growth-regulating complex involving the long TSC22DF protein BunA and the adapter molecule Madm.
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