ArticleHealth and quality of life outcomes2010
Exploring the validity of estimating EQ-5D and SF-6D utility values from the health assessment questionnaire in patients with inflammatory arthritis.
Article in Health and quality of life outcomes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Trial
- Mapping the PedsQL™ onto the CHU9D: An Assessment of External Validity in a Large Community-Based Sample.PharmacoEconomics · 2019Article
- An empirical evaluation of the SF-12, SF-6D, EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand.Health and quality of life outcomes · 2017Article
- Assessing the external validity of algorithms to estimate EQ-5D-3L from the WOMAC.Health and quality of life outcomes · 2016Article
- Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Mapping chronic liver disease questionnaire scores onto SF-6D utility values in patients with primary sclerosing cholangitis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Mapping the disease-specific LupusQoL to the SF-6D.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Tapering and discontinuation of methotrexate in patients with RA treated with TNF inhibitors: data from the DREAM registry.RMD open · 2015Article
- Article
- Treating to the target of remission in early rheumatoid arthritis is cost-effective: results of the DREAM registry.BMC musculoskeletal disorders · 2013Article
- The relationship between EQ-5D, HAQ and pain in patients with rheumatoid arthritis.Rheumatology (Oxford, England) · 2013Article
- Longitudinal predictive ability of mapping models: examining post-intervention EQ-5D utilities derived from baseline MHAQ data in rheumatoid arthritis patients.The European journal of health economics : HEPAC : health economics in prevention and care · 2013Article
- Health-related quality of life (EQ-5D) before and after orthopedic surgery.Acta orthopaedica · 2011Article
- [Immunomodulatory therapy improves quality of life with rheumatoid arthritis].Zeitschrift fur Rheumatologie · 2010Review
- Use of Bayesian multivariate meta-analysis to estimate the HAQ for mapping onto the EQ-5D questionnaire in rheumatoid arthritis.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes ResearchArticle
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Authors and funding
6 authors.
Funding
Abstract
backgroundUtility scores are used to estimate Quality Adjusted Life Years (QALYs), applied in determining the cost-effectiveness of health care interventions. In studies where no preference based measures are collected, indirect methods have been developed to estimate utilities from clinical instruments. The aim of this study was to evaluate a published method of estimating the EuroQol-5D (EQ-5D) and Short Form-6D (SF-6D) (preference based) utility scores from the Health Assessment Questionnaire (HAQ) in patients with inflammatory arthritis.
methodsData were used from 3 cohorts of patients with: early inflammatory arthritis (<10 weeks duration); established (>5 years duration) stable rheumatoid arthritis (RA); and RA being treated with anti-TNF therapy. Patients completed the EQ-5D, SF-6D and HAQ at baseline and a follow-up assessment. EQ-5D and SF-6D scores were predicted from the HAQ using a published method. Differences between predicted and observed EQ-5D and SF-6D scores were assessed using the paired t-test and linear regression.
resultsPredicted utility scores were generally higher than observed scores (range of differences: EQ-5D 0.01 - 0.06; SF-6D 0.05 - 0.10). Change between predicted values of the EQ-5D and SF-6D corresponded well with observed change in patients with established RA. Change in predicted SF-6D scores was, however, less than half of that in observed values (p < 0.001) in patients with more active disease. Predicted EQ-5D scores underestimated change in cohorts of patients with more active disease.
conclusionPredicted utility scores overestimated baseline values but underestimated change. Predicting utility values from the HAQ will therefore likely underestimate the QALYs of interventions, particularly for patients with active disease. We recommend the inclusion of at least one preference based measure in future clinical studies.
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