ArticleCritical care (London, England)2010
Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Neuroinflammatory Mechanisms of Adult Sepsis-Associated Encephalopathy: Implications for Blood-Brain Barrier Disruption and Oxidative Stress.Diagnostics (Basel, Switzerland) · 2025Review
- Neurological, metabolic and inflammatory phenotypes in a mouse model of ECHS1 deficiency.Brain communications · 2025Article
- Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood-brain barrier permeability in female CLP mice.Intensive care medicine experimental · 2024Article
- Review
- Sepsis-induced modulation of long-term potentiation induced by theta burst stimulation in the rat hippocampus.Frontiers in neuroscience · 2023Article
- Central role of microglia in sepsis-associated encephalopathy: From mechanism to therapy.Frontiers in immunology · 2022Review
- Sepsis-Associated Brain Dysfunction: A Review of Current Literature.International journal of environmental research and public health · 2020Review
- Sepsis Associated Delirium.Medicina (Kaunas, Lithuania) · 2020Review
- Septic Encephalopathy.Current neurology and neuroscience reports · 2018Review
- What we know: the inflammatory basis of hepatic encephalopathy.Metabolic brain disease · 2016Review
- Differential effects of low-phenylalanine protein sources on brain neurotransmitters and behavior in C57Bl/6-Pah(enu2) mice.Molecular genetics and metabolism · 2014Article
- Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress.PloS one · 2012Article
- Sepsis-associated encephalopathy.Translational medicine @ UniSa · 2012Article
- Neuro-oxidative-nitrosative stress in sepsis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Review
- Year in review 2010: Critical Care--Neurocritical care.Critical care (London, England) · 2011Review
- Sepsis-associated encephalopathy: not just delirium.Clinics (Sao Paulo, Brazil) · 2011Review
- Does proteolysis explain glutamine release from the septic brain?Critical care (London, England) · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.
methodsThe BCAA/AAA ratio, the cerebral delivery, and net exchange of LNAAs and ammonia were measured before and 1 hour after a 4-hour intravenous infusion of Escherichia coli lipopolysaccharide (LPS) in 12 healthy young men.
resultsLPS induced systemic inflammation, reduced the BCAA/AAA ratio, increased the cerebral delivery and unidirectional influx of phenylalanine, and abolished the net cerebral influx of the BCAAs leucine and isoleucine. Furthermore, a net cerebral efflux of glutamine, which was independent of the cerebral net exchange of ammonia, was present after LPS infusion.
conclusionsSystemic inflammation may affect brain function by reducing the BCAA/AAA ratio, thereby changing the cerebral net exchange of LNAAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.