ArticleAddiction (Abingdon, England)2010
How does variability in alcohol consumption over time affect the relationship with mortality and coronary heart disease?
Article in Addiction (Abingdon, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03133689 (Alcohol Consumption and Time-to-onset for Coronary Heart Disease), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Alcohol Consumption and Time-to-onset for Coronary Heart Disease: An Individual Participant Data Meta-analysis
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of longitudinal alcohol consumption trajectories with coronary heart disease: a meta-analysis of six cohort studies using individual participant data.BMC medicine · 2018Pooled it
- Normal liver enzymes do not indicate safety from alcohol-related liver disease: evidence from a Korean nationwide cohort.Epidemiology and health · 2026Article
- Trajectories of alcohol consumption in relation to all-cause mortality in patients with cardiovascular disease: a 35-year prospective cohort study.Addiction (Abingdon, England) · 2022Article
- Nine-Year Ethanol Intake Trajectories and Their Association With 15-Year Cognitive Decline Among Black and White Adults.American journal of epidemiology · 2020Article
- The stability of baseline-defined categories of alcohol consumption during the adult life-course: a 28-year prospective cohort study.Addiction (Abingdon, England) · 2018Observational
- Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study.Journal of internal medicine · 2017Article
- Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: prospective cohort study.BMJ (Clinical research ed.) · 2016Article
- Reliability of a retrospective decade-based life-course alcohol consumption questionnaire administered in later life.Addiction (Abingdon, England) · 2015Article
- The Role of Alcohol Consumption in Regulating Circulating Levels of Adiponectin: A Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2015Article
- All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts.BMJ (Clinical research ed.) · 2015Article
- Effect of using repeated measurements of a Mediterranean style diet on the strength of the association with cardiovascular disease during 12 years: the Doetinchem Cohort Study.European journal of nutrition · 2014Article
- An exploration of the dynamic longitudinal relationship between mental health and alcohol consumption: a prospective cohort study.BMC medicine · 2014Article
- Focus on: The cardiovascular system: what did we learn from the French (Paradox)?Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2010Review
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Abstract
objectiveTo examine the relationship between alcohol consumption and risk of mortality and incident coronary heart disease (CHD), taking account of variation in intake during follow-up.
methodProspective cohort study of 5411 male civil servants aged 35-55 years at entry to the Whitehall II study in 1985-88. Alcohol consumption was reported five times over a 15-year period. Mortality, fatal CHD, clinically verified incident non-fatal myocardial infarction and definite angina were ascertained during follow-up.
resultsWe found evidence that drinkers who vary their intake during follow-up, regardless of average level, have increased risk of total mortality (hazard ratio of high versus low variability 1.52: 95% CI: 1.07-2.17), but not of incident CHD. Using average consumption level, as opposed to only a baseline measure, gave slightly higher risk estimates for CHD compared to moderate drinkers at the extremes of the drinking range.
conclusionsMultiple repeated measures are required to explore the effects of variation in exposure over time. Caution is needed when interpreting risks of exposures measured only once at baseline, without consideration of changes over time.
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