ArticleAddiction (Abingdon, England)2010
Human sex differences in d-amphetamine self-administration.
Article in Addiction (Abingdon, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Lack of sex differences to the subjective effects of nitrous oxide in healthy volunteers.Drug and alcohol dependence · 2010Trial
- Sex and ovarian hormone cycles alter effects of stimulant drugs on mouse dopaminergic signaling.The Journal of clinical investigation · 2026Article
- Endocrine modulation of stimulant use: bidirectional interactions within the hypothalamic-pituitary-gonadal axis.Frontiers in behavioral neuroscience · 2026Review
- Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect.Pharmacological reviews · 2023Review
- Female-specific pharmacotherapy in ADHD: premenstrual adjustment of psychostimulant dosage.Frontiers in psychiatry · 2023Article
- Reward-enhancing effects of d-amphetamine and its interactions with nicotine were greater in female rats and persisted across schedules of reinforcement.Behavioural pharmacology · 2021Article
- Subjective responses predict d-amphetamine choice in healthy volunteers.Pharmacology, biochemistry, and behavior · 2021Article
- Amphetamine Promotes Cortical Up State in Part Via Dopamine Receptors.Frontiers in pharmacology · 2021Article
- Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women.Biomolecules & therapeutics · 2020Review
- Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking.The international journal of neuropsychopharmacology · 2019Article
- Sex and gender differences in substance use disorders.Clinical psychology review · 2018Review
- Gender-related differences in addiction: a review of human studies.Current opinion in behavioral sciences · 2018Article
- The effects of oral d-amphetamine on impulsivity in smoked and intranasal cocaine users.Drug and alcohol dependence · 2016Article
- Emergence of sex differences in the development of substance use and abuse during adolescence.Pharmacology & therapeutics · 2015Review
- The pharmacokinetics of methamphetamine self-administration in male and female rats.Drug and alcohol dependence · 2015Article
- Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments.Frontiers in psychiatry · 2015Review
- Importance of sex differences in impulse control and addictions.Frontiers in psychiatry · 2015Review
- Sex Differences in the Reinstatement of Methamphetamine Seeking after Forced Abstinence in Sprague-Dawley Rats.Frontiers in psychiatry · 2015Article
- Effects of adolescent nicotine exposure and withdrawal on intravenous cocaine self-administration during adulthood in male C57BL/6J mice.Addiction biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledWomen and men may respond differently to the effects of stimulants such as amphetamine and cocaine.
aimIn order to assess potential sex differences in the reinforcing effects of d-amphetamine, a retrospective-analysis was conducted on data collected from three studies that employed similar d-amphetamine self-administration procedures and used identical subject-rated drug-effect measures.
methodsData from 10 women and 15 men were included in the analysis. In all studies, participants sampled placebo, low (8-10 mg) or high (16-20 mg) dose oral d-amphetamine. Following sampling sessions, participants worked for capsules containing one eighth of the previously sampled dose on a modified progressive-ratio schedule of reinforcement. We hypothesized that women and men would be differentially sensitive to the reinforcing effects of d-amphetamine. A two-way mixed-model analysis of variance (sex and dose) and planned comparisons were used in the statistical analyses.
resultsThe low dose of d-amphetamine functioned as a reinforcer in women, but not men, whereas the high dose of d-amphetamine functioned as a reinforcer in men, but not women. Men self-administered significantly more capsules under the high dose condition than women.
conclusionThe results of this study suggest that men are more sensitive to the reinforcing effects of a high dose of d-amphetamine than women. Future research is needed that determines prospectively the reinforcing effects of weight-adjusted doses of d-amphetamine in women and men while controlling for menstrual cycle phase.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.