Evidence map›Paper›PMID 20148638›Full record

ReviewNanomedicine (London, England)2010

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention.

Tewodros Mamo, E Ashley Moseman, Nagesh Kolishetti, Carolina Salvador-Morales, Jinjun Shi, Daniel R Kuritzkes, Robert Langer, Ulrich von Andrian, Omid C Farokhzad

Open access · greenAbstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 248 citations in OpenAlex.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tewodros MamoLaboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
E Ashley Moseman
Nagesh Kolishetti
Carolina Salvador-Morales
Jinjun Shi
Daniel R Kuritzkes
Robert Langer
Ulrich von Andrian
Omid C Farokhzad
Massachusetts Institute of Technology · USHarvard University · USBrigham and Women's Hospital · USUniversity of Waterloo · CA

Funding

TREATMENT OF CANCER WITH siRNA DELVIERED BY NANOPARTICLESU54CA119349 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELCHER, ANGELA M. · 2005 to 2009
$20.5M
TRAINING PROGRAM IN MOLECULAR HEMATOLOGYT32HL007623 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI HANDIN, ROBERT I · 1985 to 2010
$7.0M
T Cell Activation in Lymph NodesR01AI069259 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI VON ANDRIAN, ULRICH H · 2006 to 2015
$4.5M
Differentiation and Regulation of CTLR01AI072252 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2007 to 2011
$2.1M
Development of Disease-Specific Drug Delivery VehiclesK08EB003647 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI FAROKHZAD, OMID C · 2005 to 2009
$964k
NCI NIH HHS U54 CA119349NCI NIH HHS U54-CA119349NHLBI NIH HHS T32 HL007623NHLBI NIH HHS T32 HL07623NIAID NIH HHS R01 AI069259NIAID NIH HHS R01 AI072252NIBIB NIH HHS EB003647NIBIB NIH HHS K08 EB003647
6 · The paper itself

Abstract

Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century. It has a vast potential to radically advance the treatment and prevention of HIV/AIDS. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for HIV/AIDS by advancing antiretroviral therapy, gene therapy, immunotherapy, vaccinology and microbicides.

Indexed as

Acquired Immunodeficiency SyndromeAnimalsAnti-Retroviral AgentsCommunicable Disease ControlFemaleGenetic TherapyGene Transfer TechniquesHIV InfectionsHumansImmunotherapyMaleNanomedicineNanotechnologyRNA, Small InterferingAnti-Retroviral AgentsRNA, Small Interfering

Identifiers

PMID20148638
PMCPMC2861897
OpenAlexW2094146325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.