ArticleACS nano2010
Nano-optofluidic detection of single viruses and nanoparticles.
Article in ACS nano, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Current status and future prospects of non-toxicity carbon-dot-based miniaturized lasers.National science review · 2025Review
- The Emergence of Nanofluidics for Single-Biomolecule Manipulation and Sensing.Analytical chemistry · 2025Review
- Exploring Carbon Dots: Green Nanomaterials for Unconventional Lasing.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- Viewing life without labels under optical microscopes.Communications biology · 2023Review
- Label-free nanofluidic scattering microscopy of size and mass of single diffusing molecules and nanoparticles.Nature methods · 2022Article
- Trench field-effect transistors integrated in a microfluidic channel and design considerations for charge detection.Applied physics letters · 2022Article
- Opportunities and Pitfalls of Fluorescent Labeling Methodologies for Extracellular Vesicle Profiling on High-Resolution Single-Particle Platforms.International journal of molecular sciences · 2021Article
- On-Chip Optical Detection of Viruses: A Review.Advanced photonics research · 2021Article
- 3D nanointerface enhanced optical microfiber for real-time detection and sizing of single nanoparticles.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2021Article
- Will Technology Rather Than Vaccination Be the Way to Control Pandemics?Infectious microbes & diseases · 2020Article
- An Analysis Review of Detection Coronavirus Disease 2019 (COVID-19) Based on Biosensor Application.Sensors (Basel, Switzerland) · 2020Review
- Advances in Label-Free Detections for Nanofluidic Analytical Devices.Micromachines · 2020Review
- Increased Flexibility in Lab-on-Chip Design with a Polymer Patchwork Approach.Nanomaterials (Basel, Switzerland) · 2019Article
- Electron-Beam-Lithographed Nanostructures as Reference Materials for Label-Free Scattered-Light Biosensing of Single Filoviruses.Sensors (Basel, Switzerland) · 2018Article
- A New Label-Free Technique for Analysing Evaporation Induced Self-Assembly of Viral Nanoparticles Based on Enhanced Dark-Field Optical Imaging.Nanomaterials (Basel, Switzerland) · 2017Article
- Label-free detection and manipulation of single biological nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Using optical trap to measure the refractive index of a single animal virus in culture fluid with high precision.Biomedical optics express · 2016Article
- Liquid Core ARROW Waveguides: A Promising Photonic Structure for Integrated Optofluidic Microsensors.Micromachines · 2016Review
- Article
- Highly sensitive detection of nanoparticles with a self-referenced and self-heterodyned whispering-gallery Raman microlaser.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The reliable detection, sizing, and sorting of viruses and nanoparticles is important for biosensing, environmental monitoring, and quality control. Here we introduce an optical detection scheme for the real-time and label-free detection and recognition of single viruses and larger proteins. The method makes use of nanofluidic channels in combination with optical interferometry. Elastically scattered light from single viruses traversing a stationary laser focus is detected with a differential heterodyne interferometer and the resulting signal allows single viruses to be characterized individually. Heterodyne detection eliminates phase variations due to different particle trajectories, thus improving the recognition accuracy as compared to standard optical interferometry. We demonstrate the practicality of our approach by resolving nanoparticles of various sizes, and detecting and recognizing different species of human viruses from a mixture. The detection system can be readily integrated into larger nanofluidic architectures for practical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.