ArticleJournal of the American Chemical Society2010
Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Designing Microflowreactors for Photocatalysis Using Sonochemistry: A Systematic Review Article.Molecules (Basel, Switzerland) · 2019Pooled it
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- Self-Driving Laboratories for Chemistry and Materials Science.Chemical reviews · 2024Review
- On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale.Sensors (Basel, Switzerland) · 2024Review
- Homogeneous, heterogeneous, and enzyme catalysis in microfluidics droplets.Smart molecules : open access · 2023Review
- Accelerated Chemical Reaction Optimization Using Multi-Task Learning.ACS central science · 2023Article
- A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries.Beilstein journal of organic chemistry · 2021Review
- Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications.Molecules (Basel, Switzerland) · 2020Review
- Electrochemical Reoxidation Enables Continuous Methane-to-Methanol Catalysis with Aqueous Pt Salts.ACS central science · 2019Article
- Machine learning and molecular descriptors enable rational solvent selection in asymmetric catalysis.Chemical science · 2019Article
- Designing Algorithms To Aid Discovery by Chemical Robots.ACS central science · 2018Review
- Challenges and opportunities for alkane functionalisation using molecular catalysts.Chemical science · 2018Review
- Click Chemistry Approaches to Expand the Repertoire of PEG-based Fluorinated Surfactants for Droplet Microfluidics.RSC advances · 2018Article
- Suzuki-Miyaura cross-coupling optimization enabled by automated feedback.Reaction chemistry & engineering · 2016Article
- Combinatorial microfluidic droplet engineering for biomimetic material synthesis.Science advances · 2016Article
- Synergy of Microfluidics and Ultrasound : Process Intensification Challenges and Opportunities.Topics in current chemistry (Cham) · 2016Review
- Evolution of oil droplets in a chemorobotic platform.Nature communications · 2014Article
- The past, present and potential for microfluidic reactor technology in chemical synthesis.Nature chemistry · 2013Review
- Microfluidics: Exploiting elephants in the room.Nature · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This paper uses microfluidics to implement genetic algorithms (GA) to discover new homogeneous catalysts using the oxidation of methane by molecular oxygen as a model system. The parameters of the GA were the catalyst, a cocatalyst capable of using molecular oxygen as the terminal oxidant, and ligands that could tune the catalytic system. The GA required running hundreds of reactions to discover and optimize catalyst systems of high fitness, and microfluidics enabled these numerous reactions to be run in parallel. The small scale and volumes of microfluidics offer significant safety benefits. The microfluidic system included methods to form diverse arrays of plugs containing catalysts, introduce gaseous reagents at high pressure, run reactions in parallel, and detect catalyst activity using an in situ indicator system. Platinum(II) was identified as an active catalyst, and iron(II) and the polyoxometalate H(5)PMo(10)V(2)O(40) (POM-V2) were identified as active cocatalysts. The Pt/Fe system was further optimized and characterized using NMR experiments. After optimization, turnover numbers of approximately 50 were achieved with approximately equal production of methanol and formic acid. The Pt/Fe system demonstrated the compatibility of iron with the entire catalytic cycle. This approach of GA-guided evolution has the potential to accelerate discovery in catalysis and other areas where exploration of chemical space is essential, including optimization of materials for hydrogen storage and CO(2) capture and modifications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.