ArticleJournal of the American Chemical Society2010
RNA conformation in catalytically active human telomerase.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Telomerase Regulation from Beginning to the End.Genes · 2016Review
- Human telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template.Nucleic acids research · 2016Article
- Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPE.RNA (New York, N.Y.) · 2015Article
- Article
- Different fluorophore labeling strategies and designs affect millisecond kinetics of DNA hairpins.Molecules (Basel, Switzerland) · 2014Article
- Unraveling secrets of telomeres: one molecule at a time.DNA repair · 2014Review
- Single-molecule fluorescence resonance energy transfer studies of the human telomerase RNA pseudoknot: temperature-/urea-dependent folding kinetics and thermodynamics.The journal of physical chemistry. B · 2014Article
- Single-molecule FRET reveals the folding dynamics of the human telomerase RNA pseudoknot domain.Angewandte Chemie (International ed. in English) · 2012Article
- Functional importance of telomerase pseudoknot revealed by single-molecule analysis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Single-molecule analysis of telomerase structure and function.Current opinion in chemical biology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
We have used single-molecule fluorescence microscopy to study the folded state of human telomerase RNA (hTR). Here we show that hTR adopts a new conformation on binding to human telomerase reverse transcriptase (hTERT) and reconstitution of an active ribonucleoprotein complex. Our data are consistent with the formation of an RNA pseudoknot in active human telomerase.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.