ArticleJournal of neurology2010
Central pontine and extrapontine myelinolysis: from epileptic and other manifestations to cognitive prognosis.
Article in Journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment of acute hypernatremia caused by sodium overload in adults: A systematic review.Medicine · 2022Pooled it
- Central pontine myelinolysis in anorexia nervosa: case report of a Chinese adolescent.Journal of eating disorders · 2024Article
- Osmotic demyelination syndrome: clinical and neuroimaging characteristics in a series of 8 cases.Quantitative imaging in medicine and surgery · 2023Article
- [Dysnatremia].Die Anaesthesiologie · 2023Article
- Article
- Acute and Chronic Hyponatremia.Frontiers in medicine · 2021Review
- How low can you go? Severe hyponatremia with a sodium of 94 mg/dL corrected with proactive strategy.Journal of community hospital internal medicine perspectives · 2020Article
- Role of Risk Factors in Developing Osmotic Demyelination Syndrome During Correction of Hyponatremia: A Case Study.Cureus · 2020Article
- Favorable Outcomes Following the Use of Triple Therapy in a Patient with Osmotic Demyelination Syndrome.Kansas journal of medicine · 2020Article
- Central Pontine Myelinosis and Osmotic Demyelination Syndrome.Deutsches Arzteblatt international · 2019Review
- Treatment of Severe Hyponatremia.Clinical journal of the American Society of Nephrology : CJASN · 2018Review
- Secondary parkinsonism in a patient of psychogenic polydipsia.BMJ case reports · 2017Article
- Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation?Annals of intensive care · 2015Article
- Use of desmopressin acetate in severe hyponatremia in the intensive care unit.Clinical journal of the American Society of Nephrology : CJASN · 2014Observational
- Molecular and neurologic responses to chronic alcohol use.Handbook of clinical neurology · 2014Review
- Clinical semiology and neuroradiologic correlates of acute hypernatremic osmotic challenge in adults: a literature review.AJNR. American journal of neuroradiology · 2013Review
- Acute brachial neuritis with central pontine and extrapontine myelinolysis in a renal transplant recipient.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Wide central pontine, bulbar and thalamic myelinolysis with sequela.The Eurasian journal of medicine · 2012Article
- [Severe hypernatremia. Case report, pathophysiology and therapy].Der Anaesthesist · 2012Article
- MRI findings of corticosubcortical lesions in osmotic myelinolysis: report of two cases.The British journal of radiology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to review the presentation, outcome and aetiology of central pontine and extrapontine myelinolysis (CPEPM) in a tertiary hospital center. The study method is a case series and included identification of patients from University of Montreal Health Centre archives database (1995-2007). All diagnoses were confirmed by neuroimaging or brain autopsy. Twelve individuals (25-66 years old) presented heterogeneous manifestations. Co-morbidities included diabetes insipidus (n = 2), haemodialysis (n = 1), cirrhosis (n = 3), gastroenteritis (n = 2) and potomania (n = 1). Aetiologies included rapid correction of severe hyponatremia (n = 6)/acute hypernatremia (n = 1); immediate (n = 2) or remote (n = 1 with recurrent cirrhosis) orthotopic liver transplantation (OLT) with tacrolimus-induced immunosuppression (n = 3); and chronic alcoholism (n = 4, two with hyponatremia). Four individuals died acutely. Two were lost to follow-up. Six had good motor or cerebellar recovery. Neuropsychological evaluations (n = 5/6) revealed a subcortical/frontal dysfunction. Cognitive impairment represented the major remaining lasting sequel (n = 4). Three salient clinical syndromes were observed: (1) predominant cerebellar presentation in individuals with alcoholism (n = 4); (2) significant alteration of consciousness at presentation (n = 4), all resulting in death (OLT, n = 3); (3) seizures persisting after natremia correction (n = 2). Clinical presentation of CPEPM is heterogeneous and can even include seizures. Cognitive impairment should be screened as it is a significant factor limiting return to normal life.
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Registered trials
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