ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2010
Epidemiology and imaging of the subchondral bone in articular cartilage repair.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Subchondral drilling for articular cartilage repair: a systematic review of translational research.Disease models & mechanisms · 2018Pooled it
- Investigation of the effects of Si-A/PUE@HA hydrogels on the osteochondral defect microenvironment based on single-cell RNA sequencing.Journal of nanobiotechnology · 2025Article
- Conservative treatments of bone marrow lesions.Journal of experimental orthopaedics · 2025Article
- Advances in the Treatment of Partial-Thickness Cartilage Defect.International journal of nanomedicine · 2022Review
- Porous 3D Scaffolds Enhance MSC Vitality and Reduce Osteoclast Activity.Molecules (Basel, Switzerland) · 2021Article
- Cyst formation in the subchondral bone following cartilage repair.Clinical and translational medicine · 2020Review
- An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery andBioactive materials · 2020Article
- Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway.International journal of molecular sciences · 2017Article
- Fluorescence molecular tomography of DiR-labeled mesenchymal stem cell implants for osteochondral defect repair in rabbit knees.European radiology · 2017Article
- Andrographolide enhances proliferation and prevents dedifferentiation of rabbit articular chondrocytes: an in vitro study.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- The relationship between patellofemoral and tibiofemoral morphology and gait biomechanics following arthroscopic partial medial meniscectomy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Article
- Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage.Cartilage · 2012Article
- Patellofemoral and tibiofemoral articular cartilage and subchondral bone health following arthroscopic partial medial meniscectomy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Article
- An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis.Arthritis research & therapy · 2012Article
- Cartilage repair and joint preservation: medical and surgical treatment options.Deutsches Arzteblatt international · 2011Review
- Scanty integration of osteochondral allografts cryopreserved at low temperatures with dimethyl sulfoxide.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2011Article
- The subchondral bone: a new frontier in articular cartilage repair.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2010Article
- Knee osteochondritis dissecans-treatment technical aspects.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Articular cartilage and the subchondral bone act as a functional unit. Following trauma, osteochondritis dissecans, osteonecrosis or osteoarthritis, this intimate connection may become disrupted. Osteochondral defects-the type of defects that extend into the subchondral bone-account for about 5% of all articular cartilage lesions. They are very often caused by trauma, in about one-third of the cases by osteoarthritis and rarely by osteochondritis dissecans. Osteochondral defects are predominantly located on the medial femoral condyle and also on the patella. Frequently, they are associated with lesions of the menisci or the anterior cruciate ligament. Because of the close relationship between the articular cartilage and the subchondral bone, imaging of cartilage defects or cartilage repair should also focus on the subchondral bone. Magnetic resonance imaging is currently considered to be the key modality for the evaluation of cartilage and underlying subchondral bone. However, the choice of imaging technique also depends on the nature of the disease that caused the subchondral bone lesion. For example, radiography is still the golden standard for imaging features of osteoarthritis. Bone scintigraphy is one of the most valuable techniques for early diagnosis of spontaneous osteonecrosis about the knee. A CT scan is a useful technique to rule out a possible depression of the subchondral bone plate, whereas a CT arthrography is highly accurate to evaluate the stability of the osteochondral fragment in osteochondritis dissecans. Particularly for the problem of subchondral bone lesions, image evaluation methods need to be refined for adequate and reproducible analysis. This article highlights recent studies on the epidemiology and imaging of the subchondral bone, with an emphasis on magnetic resonance imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.