Evidence map›Paper›PMID 20148275›Full record

ReviewEuropean child & adolescent psychiatry2010

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder.

Nanda N J Rommelse, Barbara Franke, Hilde M Geurts, Catharina A Hartman, Jan K Buitelaar

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European child & adolescent psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02618135 (Effectiveness of a Brain-Computer Interface-based Programme for the Treatment of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children), which is not on this map. Cited by 273 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
273citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02618135 nacompletednot on this mapstarted 2016, after this paper: background citation

Effectiveness of a Brain-Computer Interface-based Programme for the Treatment of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children: A Pilot Study

TypeinterventionalSponsorDuke-NUS Graduate Medical SchoolRan2016 to 2018Enrolled20ConditionsAttention Deficit Hyperactivity Disorder, Autism Spectrum DisordersArmsIntervention Group, Control Group
3 · Its place in the literature

Who cites it

273 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  14. Visual function and autism spectrum disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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213 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Nanda N J RommelseDepartment of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Reinier Postlaan 10, Nijmegen, The Netherlands. n.lambregts-rommelse@psy.umcn.nl
Barbara Franke
Hilde M Geurts
Catharina A Hartman
Jan K Buitelaar

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders. Evidence indicates both disorders co-occur with a high frequency, in 20-50% of children with ADHD meeting criteria for ASD and in 30-80% of ASD children meeting criteria for ADHD. This review will provide an overview on all available studies [family based, twin, candidate gene, linkage, and genome wide association (GWA) studies] shedding light on the role of shared genetic underpinnings of ADHD and ASD. It is concluded that family and twin studies do provide support for the hypothesis that ADHD and ASD originate from partly similar familial/genetic factors. Only a few candidate gene studies, linkage studies and GWA studies have specifically addressed this co-occurrence, pinpointing to some promising pleiotropic genes, loci and single nucleotide polymorphisms (SNPs), but the research field is in urgent need for better designed and powered studies to tackle this complex issue. We propose that future studies examining shared familial etiological factors for ADHD and ASD use a family-based design in which the same phenotypic (ADHD and ASD), candidate endophenotypic, and environmental measurements are obtained from all family members. Multivariate multi-level models are probably best suited for the statistical analysis.

Indexed as

ActigraphyAdolescentAttention Deficit Disorder with HyperactivityAutistic DisorderChildComorbidityGenetic MarkersGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPersonality AssessmentPhenotypePolymorphism, Single NucleotideRisk AssessmentSocial EnvironmentGenetic Markers

Identifiers

PMID20148275
PMCPMC2839489

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.