ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010
A new concept for the differential diagnosis and therapy of anaemia in cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Erythropoietin or darbepoetin for patients with cancer.The Cochrane database of systematic reviews · 2012Pooled it
- Take into Account Variations of Transferrin Saturation.Deutsches Arzteblatt international · 2022Article
- Ferric ion detection mechanism of a dicarboxylic cellulose nanocrystal and a 7-amino-4-methylcoumarin based fluorescent chemosensor.RSC advances · 2022Article
- TAM-ing the CIA-Tumor-Associated Macrophages and Their Potential Role in Unintended Side Effects of Therapeutics for Cancer-Induced Anemia.Frontiers in oncology · 2021Article
- Flipside of the Coin: Iron Deficiency and Colorectal Cancer.Frontiers in immunology · 2021Review
- Clinical use of ferric carboxymaltose in patients with solid tumours or haematological malignancies in France.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Observational
- Article
- Iron metabolism and iron supplementation in cancer patients.Wiener klinische Wochenschrift · 2015Review
- Analysis of salivary fluid and chemosensory functions in patients treated for primary malignant brain tumors.Clinical oral investigations · 2015Article
- The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study.Haematologica · 2015Observational
- Using the hemoglobin content of reticulocytes (RET-He) to evaluate anemia in patients with cancer.American journal of clinical pathology · 2014Article
- Iron deficiency in patients with solid tumours: prevalence and management in clinical practice.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Observational
- Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- Association between serum levels of C-reactive protein and response to treatment of chemotherapy-induced anemia in patients with solid tumors: a multicenter, prospective, observational study.Medical oncology (Northwood, London, England) · 2013Article
- Clinical experience with ferric carboxymaltose in the treatment of cancer- and chemotherapy-associated anaemia.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- Diagnosis of anaemia: old things rearranged.Wiener medizinische Wochenschrift (1946) · 2012Review
- The role of intravenous iron in the treatment of anemia in cancer patients.Therapeutic advances in hematology · 2012Article
- Iron deficiency in gastrointestinal oncology.Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to prove the usefulness of the diagnostic plot, using the haemoglobin content of reticulocytes as a measure of functional iron deficiency (FID) and the ferritin index as a measure of iron availability, to customise anaemia treatment in cancer patients.
methodsBased on results of this plot, cancer patients fulfilling practice guideline criteria to receive erythropoiesis-stimulating agents (ESAs) were allocated to treatment with ESAs alone, iron alone or the combination of both. Primary endpoint was the percentage of patients identified to require iron in addition or as an alternative to ESA therapy.
resultsOut of 303 patients screened, 286 were allocated to treatment: 204 patients were normochromic and iron replete and treated with ESAs alone, 22 had both FID and anaemia of chronic disease and were treated with ESAs and parenteral iron, and 60 were iron-depleted and treated with iron only. After 8 weeks, a haemoglobin increase >1 g/dL from baseline was shown by 56% of patients treated with ESAs alone, by 100% of patients receiving the combination, by 50% of normochromic and by 73% of hypochromic iron-depleted patients receiving iron only. Acute phase reaction did not diminish the response rate to ESAs.
conclusionsThe diagnostic plot was superior to transferrin saturation and ferritin in predicting iron availability in hypochromic patients treated with ESAs and proved useful to select treatment for anaemia in cancer patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.