ArticleExperimental diabetes research2009
The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy.
Article in Experimental diabetes research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 81 citations in OpenAlex.
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- Alleviative Effect ofPlants (Basel, Switzerland) · 2023Article
- Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena.Journal of diabetes · 2023Review
- COMPARATIVE EFFECT OF A HIGH FAT WITH OR WITHOUT HIGH LEVELS OF SUCROSE DIETS ON PERIPHERAL NEUROPATHY IN C57BL/6J MICE.Journal of diabetic complications & therapy · 2022Article
- Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats.Neurochemical research · 2021Article
- Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Article
- Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals.Diabetes & metabolism journal · 2021Review
- Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice.The Journal of pharmacology and experimental therapeutics · 2020Article
- The emergence of animal models of chronic pain and logistical and methodological issues concerning their use.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Attenuation of Cortically Evoked Motor-Neuron Potential in Streptozotocin-Induced Diabetic Rats: A Study about the Effect of Diabetes upon Cortical-Initiated Movement.BioMed research international · 2020Article
- Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes.Journal of diabetes research · 2020Article
- The Study of Pain in Rats and Mice.Comparative medicine · 2019Review
- Article
- Neprilysin inhibition: a new therapeutic option for type 2 diabetes?Diabetologia · 2019Review
- A novel curcumin derivative for the treatment of diabetic neuropathy.Neuropharmacology · 2018Article
- Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation.Drug design, development and therapy · 2018Article
- Article
- Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels.Diabetologia · 2017Article
- Epoxy fatty acids mediate analgesia in murine diabetic neuropathy.European journal of pain (London, England) · 2017Article
- Effect of Inhibition or Deletion of Neutral Endopeptidase on Neuropathic Endpoints in High Fat Fed/Low Dose Streptozotocin-Treated Mice.Journal of neuropathology and experimental neurology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
We demonstrated that inhibition of neutral endopeptidase (NEP), a protease that degrades vaso- and neuroactive peptides, improves vascular and neural function in diabetic animal models. In this study we explored the role of NEP in neuropathy related to either insulin-deficient diabetes or diet-induced obesity using NEP deficient (-/-) mice. Initial studies showed that streptozotocin, in the absence of subsequent hyperglycemia, did not induce nerve conduction slowing or paw thermal hypoalgesia. Glucose disposal was impaired in both C57Bl/6 and NEP -/- mice fed a high fat diet. Thermal hypoalgesia and nerve conduction slowing were present in both streptozotocin-diabetic and high fat fed C57Bl/6 mice but not in NEP -/- mice exposed to either streptozotocin-induced diabetes or a high fat diet. These studies suggest that streptozotocin does not induce neurotoxicity in mice and that NEP plays a role in regulating nerve function in insulin-deficient diabetes and diet-induced obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.