Evidence map›Paper›PMID 2014798›Full record

ArticleAmerican journal of human genetics1991

Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.

K Huebner, T Druck, C M Croce, H J Thiesen

Abstract read
In one paragraph

Article in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
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  6. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.Mammalian genome : official journal of the International Mammalian Genome Society · 1996
    Article
  7. Article
  8. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  9. Article
  10. Involvement of the ALL-1 gene in a solid tumor.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  11. Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 1994
    Article
  12. Article
  13. The human homologue of the retroviral oncogene qin maps to chromosome 14q13.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  14. Cloning and characterization of two members of the vertebrate Dlx gene family.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
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  19. Article
  20. A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression.Mammalian genome : official journal of the International Mammalian Genome Society · 1993
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

K HuebnerFels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140.
T Druck
C M Croce
H J Thiesen
Temple University · US

Funding

VIROLOGY AND GENETICS OF CANCERP01CA021124 · NCI · WISTAR INSTITUTE · PI KOPROWSKI, HILARY · 1985 to 1999
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GENTEICS OF HUMAN HEMATOPOIETIC NEOPLASIASR35CA039860 · NCI · WISTAR INSTITUTE · PI CROCE, CARLO M · 1985 to 1998
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NCI NIH HHS CA21124NCI NIH HHS CA39860
6 · The paper itself

Abstract

cDNA clones encoding zinc finger structures were isolated by screening Molt4 and Jurkat cDNA libraries with zinc finger consensus sequences. Candidate clones were partially sequenced to verify the presence of zinc finger-encoding regions; nonoverlapping cDNA clones were chosen on the basis of sequences and genomic hybridization pattern. Zinc finger structure-encoding clones, which were designated by the term "Kox" and a number from 1 to 32 and which were apparently unique (i.e., distinct from each other and distinct from those isolated by other laboratories), were chosen for mapping in the human genome. DNAs from rodent-human somatic cell hybrids retaining defined complements of human chromosomes were analyzed for the presence of each of the Kox genes. Correlation between the presence of specific human chromosome regions and specific Kox genes established the chromosomal locations. Multiple Kox loci were mapped to 7q (Kox 18 and 25 and a locus detected by both Kox 8 cDNA and Kox 27 cDNA), 8q24 5' to the myc locus (Kox 9 and 32), 10cen----q24 (Kox 2, 15, 19, 21, 30, and 31), 12q13-qter (Kox 1 and 20), 17p13 (Kox 11 and 26), and 19q (Kox 5, 6, 10, 22, 24, and 28). Single Kox loci were mapped to 7p22 (Kox 3), 18q12 (Kox 17), 19p (Kox 13), 22q11 between IG lambda and BCR-1 (locus detected by both Kox 8 cDNA and Kox 27 cDNA), and Xp (Kox 14). Several of the Kox loci map to regions in which other zinc finger structure-encoding loci have already been localized, indicating possible zinc finger gene clusters. In addition, Kox genes at 8q24, 17p13, and 22q11--and perhaps other Kox genes--are located near recurrent chromosomal translocation breakpoints. Others, such as those on 7p and 7q, may be near regions specifically active in T cells.

Indexed as

Multigene FamilyChromosomes, HumanDNAGenomic LibraryHumansHybrid CellsRestriction MappingStructure-Activity RelationshipT-LymphocytesTranslocation, GeneticZinc FingersDNA

Identifiers

PMID2014798
PMCPMC1682948
OpenAlexW55473063

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.