ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Confirmation and generalization of an alcohol-dependence locus on chromosome 10q.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans.Human genetics · 2013Trial
- Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry.Addiction biology · 2019Article
- Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry.Addiction (Abingdon, England) · 2015Article
- Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.Biological psychiatry · 2012Article
- Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- A genomewide linkage scan of cocaine dependence and major depressive episode in two populations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Biological psychiatry · 2011Article
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Authors and funding
8 authors at 5 institutions in 1 country.
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Abstract
Several genome scans on alcohol dependence (AD) and AD-related traits have been published. In this article, we present the results of a genome-wide linkage scan on AD and several related traits in 322 European-American (EA) families, and results of additional analysis in 335 African-American (AA) families that were the subject of a previous report. All families were initially ascertained for cocaine and/or opioid dependence. Non-parametric linkage analysis in the EA sample revealed suggestive linkages on chromosomes 7 (LOD=2.1 at 82.8 cM, p=0.0009) and 10 (LOD=3.0 at 137.7 cM, p=0.0001). The chromosome 10 linkage peak is 20 cM distal from a genome-wide significant linkage peak we observed previously in the AA sample. Parametric linkage analysis on chromosome 10 (assuming a recessive model, 80% penetrance, disease allele frequency=0.3) resulted in LOD scores of 2.7 at 136.7 cM and 1.9 at 121.7 cM in the EA and AA samples, respectively, with a combined sample genome-wide significant LOD score of 4.1 at 131.7 cM. To reduce heterogeneity of the AD phenotype, we also assessed linkage of chromosome 10 markers with the presence of alcohol withdrawal symptoms, one of the seven components of the DSM-IV diagnosis of AD. Suggestive evidence for linkage was observed in both populations with only 5 cM separating the location of the peak LOD scores despite a loss of power due to a smaller number of families informative for this trait. Results of our study confirm a chromosome 10 risk locus for AD in two genetically distinct populations and suggest that this locus may correspond more precisely to a specific component of the disorder.
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