ArticlePhysical biology2010
Robust transport by multiple motors with nonlinear force-velocity relations and stochastic load sharing.
Article in Physical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 107 citations in OpenAlex.
- Molecular Motors Orchestrate Pause-and-Run Dynamics to Facilitate Intracellular Transport.Biomolecules · 2026Article
- Molecular motors orchestrate pause-and-run dynamics to facilitate intracellular transport.bioRxiv : the preprint server for biology · 2025Article
- Nuclear deformation by microtubule molecular motors.PLoS computational biology · 2025Article
- Optimal strategies for correcting merotelic chromosome attachments in anaphase.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- On the use of thermal forces to probe kinesin's response to force.Frontiers in molecular biosciences · 2023Article
- Cargo surface fluidity can reduce inter-motor mechanical interference, promote load-sharing and enhance processivity in teams of molecular motors.PLoS computational biology · 2022Article
- Coordinated motion of molecular motors on DNA chains with branch topology.Acta mechanica Sinica = Li xue xue bao · 2022Article
- A change point analysis protocol for comparing intracellular transport by different molecular motor combinations.Mathematical biosciences and engineering : MBE · 2021Article
- Effective behavior of cooperative and nonidentical molecular motors.Research in the mathematical sciences · 2020Article
- Renewal Reward Perspective on Linear Switching Diffusion Systems in Models of Intracellular Transport.Bulletin of mathematical biology · 2020Article
- Modelling cytoskeletal transport by clusters of non-processive molecular motors with limited binding sites.Royal Society open science · 2020Article
- Article
- Load-dependent detachment kinetics plays a key role in bidirectional cargo transport by kinesin and dynein.Traffic (Copenhagen, Denmark) · 2019Article
- Rotation of endosomes demonstrates coordination of molecular motors during axonal transport.Science advances · 2018Article
- Cancer drug therapy and stochastic modeling of "nano-motors".International journal of nanomedicine · 2018Article
- Mechanical coupling of microtubule-dependent motor teams during peroxisome transport in Drosophila S2 cells.Biochimica et biophysica acta. General subjects · 2017Article
- Effect of fuel concentration and force on collective transport by a team of dynein motors.Protein science : a publication of the Protein Society · 2017Article
- Interrogating Emergent Transport Properties for Molecular Motor Ensembles: A Semi-analytical Approach.PLoS computational biology · 2016Article
- A Motor-Gradient and Clustering Model of the Centripetal Motility of MTOCs in Meiosis I of Mouse Oocytes.PLoS computational biology · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transport by processive molecular motors plays an important role in many cell biological phenomena. In many cases, motors work together to transport cargos in the cell, so it is important to understand the mechanics of the multiple motors. Based on earlier modeling efforts, here we study effects of nonlinear force-velocity relations and stochastic load sharing on multiple motor transport. We find that when two or three motors transport the cargo, then the nonlinear and stochastic effects compensate so that the mechanical properties of the transport are robust. Similarly, the transport is insensitive to compliance of the cargo-motor links. Furthermore, the rate of movement against moderate loads is not improved by increasing the small number of motors. When the motor number is greater than 4, correlations between the motors become negligible, and the earlier analytical mean-field theory of the multiple motor transport holds. We predict that the effective diffusion of the cargo driven by the multiple motors under load increases by an order of magnitude compared to that for the single motor. Finally, our simulations predict that the stochastic effects are responsible for a significant dispersion of velocities generated by the 'tug-of-war' of the multiple opposing motors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.