ReviewThe Journal of biological chemistry2010
Transcriptional switches: chemical approaches to gene regulation.
Review in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- OPTO-BLUE: An Integrated Bidirectional Optogenetic Lentiviral Platform for Controlled Light-Induced Gene Expression.International journal of molecular sciences · 2023Article
- The prognostic capacities of CBP and p300 in locally advanced rectal cancer.World journal of surgical oncology · 2019Article
- Covalent Chemical Cochaperones of the p300/CBP GACKIX Domain.Chembiochem : a European journal of chemical biology · 2018Article
- Dual Labeling of the CBP/p300 KIX Domain forChembiochem : a European journal of chemical biology · 2018Article
- Prepaying the entropic cost for allosteric regulation in KIX.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer.Molecular cancer · 2014Article
- The role of HTS in drug discovery at the University of Michigan.Combinatorial chemistry & high throughput screening · 2014Review
- Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Cellular and molecular life sciences : CMLS · 2013Review
- Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis.Molecular genetics and genomics : MGG · 2013Article
- Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.Angewandte Chemie (International ed. in English) · 2012Article
- Profiling the dynamic interfaces of fluorinated transcription complexes for ligand discovery and characterization.ACS chemical biology · 2012Article
- Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity.Expert reviews in molecular medicine · 2012Review
- Synergistic enhancement of the potency and selectivity of small molecule transcriptional inhibitors.ACS medicinal chemistry letters · 2012Article
- Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo.ACS chemical biology · 2011Article
- HTLV-1 HBZ protein deregulates interactions between cellular factors and the KIX domain of p300/CBP.Journal of molecular biology · 2011Article
- Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the role of transcriptional misregulation in the pathogenesis of human disease, there is enormous interest in the development of molecules that exogenously control transcription in a defined manner. The past decade has seen many exciting advancements in the identification of molecules that mimic or inhibit the interactions between natural transcriptional activators and their binding partners. In this minireview, we focus on four activator.target protein complexes, highlighting recent advances as well as challenges in the field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.