Evidence map›Paper›PMID 20147682›Full record

ArticleAmerican journal of public health2010

Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change.

Angelica P Herrera, Shedra Amy Snipes, Denae W King, Isabel Torres-Vigil, Daniel S Goldberg, Armin D Weinberg

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of public health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06609551 (ctDNA-guided Selection of Adjuvant Chemotherapy Regimens for Elderly Colon Cancer Patients After Surgery), which is not on this map. Cited by 170 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06609551 phase3recruitingnot on this mapstarted 2024, after this paper: background citation

ctDNA-guided Selection of Adjuvant Chemotherapy Regimens for Elderly Colon Cancer Patients After Surgery: A Single-center, Randomized, Controlled Study

TypeinterventionalSponsorZhejiang Cancer HospitalRan2024 to 2034Enrolled312ConditionsColon Cancer, Colon Cancer (Stage II &Amp, Amp, AmpArms6-month adjuvant chemotherapy with 5-FU monotherapy, XELOX intensive treatment group
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angelica P HerreraThe University of Texas MD Anderson Cancer Center, Houston, TX, USA. apherrera@ucsd.edu
Shedra Amy Snipes
Denae W King
Isabel Torres-Vigil
Daniel S Goldberg
Armin D Weinberg

Funding

SHARED RESOUCES COREP60MD000503 · NIMHD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JONES, LOVELL ALLAN · 2003 to 2011
$12.4M
Parenteral Hydration in Advanced Cancer Patients: A Randomized Controlled TrialR01CA122292 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRUERA, EDUARDO · 2006 to 2009
$2.2M
NCI NIH HHS R01 CA122292NIMHD NIH HHS 5 P60 MD000503NIMHD NIH HHS P60 MD000503
6 · The paper itself

Abstract

Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity.

Indexed as

BiasClinical Trials as TopicPatient SelectionPolicy MakingAgedClinical ProtocolsHumansUnited StatesUnited States Food and Drug Administration

Identifiers

PMID20147682
PMCPMC2837461

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.