ArticleAmerican journal of physiology. Cell physiology2010
Odors activate dual pathways, a TRPC2 and a AA-dependent pathway, in mouse vomeronasal neurons.
Article in American journal of physiology. Cell physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Article
- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors.Biomolecules & therapeutics · 2024Review
- Conserved Molecular Players Involved in Human Nose Morphogenesis Underlie Evolution of the Exaggerated Snout Phenotype in Cichlids.Genome biology and evolution · 2023Article
- Cyclophosphamide has Long-Term Effects on Proliferation in Olfactory Epithelia.Chemical senses · 2020Article
- Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels.Frontiers in physiology · 2017Review
- TRICK or TRP? What Trpc2(-/-) mice tell us about vomeronasal organ mediated innate behaviors.Frontiers in neuroscience · 2015Article
- Article
- The genomic basis of vomeronasal-mediated behaviour.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons.Frontiers in cellular neuroscience · 2014Article
- Phospholipase C and diacylglycerol mediate olfactory responses to amino acids in the main olfactory epithelium of an amphibian.PloS one · 2014Article
- Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.Nature neuroscience · 2012Article
- Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.The Journal of biological chemistry · 2012Article
- Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons.Nature communications · 2011Article
- Emerging roles of canonical TRP channels in neuronal function.Advances in experimental medicine and biology · 2011Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Located at the anterior portion of the nose, the paired vomeronasal organs (VNO) detect odors and pheromones. In vomeronasal sensory neurons (VSNs) odor responses are mainly mediated by phospholipase C (PLC), stimulation of which elevates diacylglycerol (DAG). DAG activates a transient receptor potential channel (TRPC2) leading to cell depolarization. In this study, we used a natural stimulus, urine, to elicit odor responses in VSNs and found urine responses persisted in TRPC2(-/-) mice, suggesting the existence of a TRPC2-independent signal transduction pathway. Using perforated patch-clamp recordings on isolated VSNs from wild-type (WT) and TRPC2(-/-) mice, we found a PLC inhibitor blocked urine responses from all VSNs. Furthermore, urine responses were reduced by blocking DAG lipase, an enzyme that produces arachidonic acid (AA), in WT mice and abolished in TRPC2(-/-) mice. Consistently, direct stimulation with AA activated an inward current that was independent of TRPC2 channels but required bath Ca(2+) and was blocked by Cd(2+). With the use of inside-out patches from TRPC2(-/-) VSNs, we show that AA activated a channel that also required Ca(2+). Together, these data from WT and TRPC2(-/-) mice suggest that both DAG and its metabolite, AA, mediate excitatory odor responses in VSNs, by activating two types of channels, a TRPC2 and a separate Ca(2+)-permeable channel.
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