ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Keeping it together: mechanisms of intersegmental coordination for a flexible locomotor behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
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- STEERING FROM THE REAR: COORDINATION OF CENTRAL PATTERN GENERATORS UNDERLYING NAVIGATION BY ASCENDING INTERNEURONS.bioRxiv : the preprint server for biology · 2024Article
- Intersegmental Interactions Give Rise to a Global Network.Frontiers in neural circuits · 2022Article
- Article
- A leech model for homeostatic plasticity and motor network recovery after loss of descending inputs.Journal of neurophysiology · 2016Article
- Sensory feedback in cockroach locomotion: current knowledge and open questions.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Compensatory plasticity restores locomotion after chronic removal of descending projections.Journal of neurophysiology · 2015Article
- Multiplexed modulation of behavioral choice.The Journal of experimental biology · 2014Article
- Mechanisms of coordination in distributed neural circuits: encoding coordinating information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mechanisms of coordination in distributed neural circuits: decoding and integration of coordinating information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Scanning behavior in the medicinal leech Hirudo verbana.PloS one · 2014Article
- Neural circuits for peristaltic wave propagation in crawling Drosophila larvae: analysis and modeling.Frontiers in computational neuroscience · 2013Article
- Necessary, sufficient and permissive: a single locomotor command neuron important for intersegmental coordination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Molluscan neurons in culture: shedding light on synapse formation and plasticity.Journal of molecular histology · 2012Review
- The brain matters: effects of descending signals on motor control.Journal of neurophysiology · 2012Article
- Specialized brain regions and sensory inputs that control locomotion in leeches.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Patterns of presynaptic activity and synaptic strength interact to produce motor output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A perimotor framework reveals functional segmentation in the motoneuronal network controlling locomotion in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neural circuits controlling behavior and autonomic functions in medicinal leeches.Neural systems & circuits · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The coordination of multiple neural oscillators is key for the generation of productive locomotor movements. In the medicinal leech, we determined that activation and coordination of the segmental crawl oscillators, or unit burst generators, are dependent on signals descending from the cephalic ganglion. In nearly intact animals, removing descending input (reversibly with a sucrose block) prevented overt crawling, but not swimming. Cephalic depolarization was sufficient for coordination. To determine whether descending signals were necessary for the generation and maintenance of posterior-directed intersegmental phase delays, we induced fictive crawling in isolated whole nerve cords using dopamine (DA) and blocked descending inputs. After blockade, we observed a significant loss of intersegmental coordination. Appropriate phase delays were also absent in DA-treated chains of ganglia. In chains, when one ganglion was removed from its neighbors, crawling in that ganglion emerged robust and stable, underscoring that these oscillators operate best with either all or none of their intersegmental inputs. To study local oscillator coupling, we induced fictive crawling (with DA) in a single oscillator within a chain. Although appropriate intersegmental phase delays were always absent, when one ganglion was treated with DA, neighboring ganglia began to show crawl-like bursting, with motoneuron spikes/burst greatest in untreated posterior ganglia. We further determined that this local excitatory drive excluded the swim-gating cell, 204. In conclusion, both long-distance descending and local interoscillator coupling contribute to crawling. This dual contribution helps to explain the inherent flexibility of crawling, and provides a foundation for understanding other dynamic locomotor behaviors across animal groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.