ArticleMolecular biology of the cell2010
Initial polarized bud growth by endocytic recycling in the absence of actin cable-dependent vesicle transport in yeast.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation.Science signaling · 2016Article
- Quantitative analysis of membrane trafficking in regulation of Cdc42 polarity.Traffic (Copenhagen, Denmark) · 2014Article
- Asymmetric distribution of phosphatidylserine is generated in the absence of phospholipid flippases in Saccharomyces cerevisiae.MicrobiologyOpen · 2014Article
- N-wasp is required for structural integrity of the blood-testis barrier.PLoS genetics · 2014Article
- Article
- Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis.Developmental cell · 2013Article
- Robust polarity establishment occurs via an endocytosis-based cortical corralling mechanism.The Journal of cell biology · 2013Article
- Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops.Nature communications · 2013Article
- Cell polarization and cytokinesis in budding yeast.Genetics · 2012Review
- Arp2/3 mediates early endosome dynamics necessary for the maintenance of PAR asymmetry in Caenorhabditis elegans.Molecular biology of the cell · 2012Article
- Article
- Morphogenesis and the cell cycle.Genetics · 2012Review
- Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.Molecular biology of the cell · 2011Article
- Polarization of the yeast pheromone receptor requires its internalization but not actin-dependent secretion.Molecular biology of the cell · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The assembly of filamentous actin is essential for polarized bud growth in budding yeast. Actin cables, which are assembled by the formins Bni1p and Bnr1p, are thought to be the only actin structures that are essential for budding. However, we found that formin or tropomyosin mutants, which lack actin cables, are still able to form a small bud. Additional mutations in components for cortical actin patches, which are assembled by the Arp2/3 complex to play a pivotal role in endocytic vesicle formation, inhibited this budding. Genes involved in endocytic recycling were also required for small-bud formation in actin cable-less mutants. These results suggest that budding yeast possesses a mechanism that promotes polarized growth by local recycling of endocytic vesicles. Interestingly, the type V myosin Myo2p, which was thought to use only actin cables to track, also contributed to budding in the absence of actin cables. These results suggest that some actin network may serve as the track for Myo2p-driven vesicle transport in the absence of actin cables or that Myo2p can function independent of actin filaments. Our results also show that polarity regulators including Cdc42p were still polarized in mutants defective in both actin cables and cortical actin patches, suggesting that the actin cytoskeleton does not play a major role in cortical assembly of polarity regulators in budding yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.