ArticleMolecular biology and evolution2010
Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- A population genomic resource for Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2026Article
- Population genomics ofbioRxiv : the preprint server for biology · 2026Article
- Development and evolution of Drosophila chromatin landscape in a 3D genome context.Nature communications · 2024Article
- A germline PAF1 paralog complex ensures cell type-specific gene expression.Genes & development · 2024Article
- Transposable element accumulation drives size differences among polymorphic Y Chromosomes inGenome research · 2022Article
- Establishment and evolution of heterochromatin.Annals of the New York Academy of Sciences · 2020Review
- Complex Evolutionary History of the Y Chromosome in Flies of the Drosophila obscura Species Group.Genome biology and evolution · 2020Article
- Sex Chromosome Evolution in Muscid Flies.G3 (Bethesda, Md.) · 2020Article
- An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera.PLoS genetics · 2018Article
- De novo assembly of a young Drosophila Y chromosome using single-molecule sequencing and chromatin conformation capture.PLoS biology · 2018Article
- Variable Rates of Simple Satellite Gains across the Drosophila Phylogeny.Molecular biology and evolution · 2018Article
- Convergent evolution of Y chromosome gene content in flies.Nature communications · 2017Article
- The house fly Y Chromosome is young and minimally differentiated from its ancient X Chromosome partner.Genome research · 2017Article
- Genomic changes following the reversal of a Y chromosome to an autosome in Drosophila pseudoobscura.Evolution; international journal of organic evolution · 2017Article
- Article
- Simple method for fluorescence DNA in situ hybridization to squashed chromosomes.Journal of visualized experiments : JoVE · 2015Article
- The organization and evolution of the Responder satellite in species of the Drosophila melanogaster group: dynamic evolution of a target of meiotic drive.BMC evolutionary biology · 2014Article
- Positive and purifying selection on the Drosophila Y chromosome.Molecular biology and evolution · 2014Article
- Recent selection on the Y-to-dot translocation in Drosophila pseudoobscura.Molecular biology and evolution · 2014Article
- Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
One of the most striking cases of sex chromosome reorganization in Drosophila occurred in the lineage ancestral to Drosophila pseudoobscura, where there was a translocation of Y-linked genes to an autosome. These genes went from being present only in males, never recombining, and having an effective population size of 0.5N to a state of autosomal linkage, where they are passed through both sexes, may recombine, and their effective population size has quadrupled. These genes appear to be functional, and they underwent a drastic reduction in intron size after the translocation. A Y-autosome translocation may pose problems in meiosis if the rDNA locus responsible for X-Y pairing had also moved to an autosome. In this study, we demonstrate that the Y-autosome translocation moved Y-linked genes onto the dot chromosome, a small, mainly heterochromatic autosome with some sex chromosome-like properties. The rDNA repeats occur exclusively on the X chromosome in D. pseudoobscura, but we found that the new Y chromosome of this species harbors four clusters bearing only the intergenic spacer region (IGS) of the rDNA repeats. This arrangement appears analogous to the situation in Drosophila simulans, where X-rDNA to Y-IGS pairing could be responsible for X-Y chromosome pairing. We postulate that the nascent D. pseudoobscura Y chromosome acquired and amplified copies of the IGS, suggesting a potential mechanism for X-Y pairing in D. pseudoobscura.
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