ArticleGenome biology2010
Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 129 citations in OpenAlex.
- How to upgrade stolen organelles into permanent plastids: A comparative transcriptomic perspective.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Circadian regulation of key physiological processes by the RITMO1 clock protein in the marine diatom Phaeodactylum tricornutum.The New phytologist · 2025Article
- Heat shock transcription factor-mediated thermal tolerance and cell size plasticity in marine diatoms.Nature communications · 2025Article
- Pennate diatoms make non-photochemical quenching as simple as possible but not simpler.Nature communications · 2025Article
- H3K27me3 and EZH Are Involved in the Control of the Heat-Stress-Elicited Morphological Changes in Diatoms.International journal of molecular sciences · 2024Article
- Spinach genomes reveal migration history and candidate genes for important crop traits.NAR genomics and bioinformatics · 2024Article
- Cryptochrome PtCPF1 regulates high temperature acclimation of marine diatoms through coordination of iron and phosphorus uptake.The ISME journal · 2024Article
- Phenotypic Analysis and Molecular Characterization of Enlarged Cell Size Mutant inInternational journal of molecular sciences · 2023Article
- Gene expression during the formation of resting spores induced by nitrogen starvation in the marine diatom Chaetoceros socialis.BMC genomics · 2023Article
- Increased genetic diversity loss and genetic differentiation in a model marine diatom adapted to ocean warming compared to high COThe ISME journal · 2022Article
- Genome evolution of a nonparasitic secondary heterotroph, the diatomScience advances · 2022Article
- Trade-off between sex and growth in diatoms: Molecular mechanisms and demographic implications.Science advances · 2022Article
- Light intensity and spectral composition drive reproductive success in the marine benthic diatom Seminavis robusta.Scientific reports · 2021Article
- Mating type specific transcriptomic response to sex inducing pheromone in the pennate diatom Seminavis robusta.The ISME journal · 2021Article
- An optimised method for intact nuclei isolation from diatoms.Scientific reports · 2021Article
- Diatom Molecular Research Comes of Age: Model Species for Studying Phytoplankton Biology and Diversity.The Plant cell · 2020Review
- A genomics approach reveals the global genetic polymorphism, structure, and functional diversity of ten accessions of the marine model diatom Phaeodactylum tricornutum.The ISME journal · 2020Article
- Quantitative Proteomic Profiling of Marine DiatomFrontiers in microbiology · 2020Article
- Genome-Wide Analysis of Cell Cycle-Regulating Genes in the Symbiotic DinoflagellateG3 (Bethesda, Md.) · 2019Article
- De novo transcriptome assembly and analysis of the freshwater araphid diatom Fragilaria radians, Lake Baikal.Scientific data · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the enormous importance of diatoms in aquatic ecosystems and their broad industrial potential, little is known about their life cycle control. Diatoms typically inhabit rapidly changing and unstable environments, suggesting that cell cycle regulation in diatoms must have evolved to adequately integrate various environmental signals. The recent genome sequencing of Thalassiosira pseudonana and Phaeodactylum tricornutum allows us to explore the molecular conservation of cell cycle regulation in diatoms.
resultsBy profile-based annotation of cell cycle genes, counterparts of conserved as well as new regulators were identified in T. pseudonana and P. tricornutum. In particular, the cyclin gene family was found to be expanded extensively compared to that of other eukaryotes and a novel type of cyclins was discovered, the diatom-specific cyclins. We established a synchronization method for P. tricornutum that enabled assignment of the different annotated genes to specific cell cycle phase transitions. The diatom-specific cyclins are predominantly expressed at the G1-to-S transition and some respond to phosphate availability, hinting at a role in connecting cell division to environmental stimuli.
conclusionThe discovery of highly conserved and new cell cycle regulators suggests the evolution of unique control mechanisms for diatom cell division, probably contributing to their ability to adapt and survive under highly fluctuating environmental conditions.
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