ArticleJournal of medicinal chemistry2010
Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives.
Article in Journal of medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 53 citations in OpenAlex.
- Indazole - an emerging privileged scaffold: synthesis and its biological significance.RSC medicinal chemistry · 2025Review
- A Structure-Activity Relationship Study of Bimodal BODIPY-Labeled PSMA-Targeting Bioconjugates.ChemMedChem · 2021Article
- Rigid Scaffolds: Synthesis of 2,6-Bridged Piperazines with Functional Groups in all three Bridges.ChemistryOpen · 2020Article
- A Highly Efficient BODIPY Based Turn-off Fluorescent Probe for Detecting CuJournal of fluorescence · 2020Article
- Expedient synthesis ofScience advances · 2019Article
- A BODIPY Based Fluorescent Probe for the Rapid Detection of Hypochlorite.Journal of fluorescence · 2018Article
- The binding orientations of structurally-related ligands can differ; A cautionary note.Neuropharmacology · 2017Article
- Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes.ACS chemical biology · 2014Article
- 4-Methyl-N-(9-methyl-9-aza-bicyclo-[3.3.1]non-3-yl)benzamide.Acta crystallographica. Section E, Structure reports online · 2012Article
- (1S*,5R*)-9-Phenyl-9-aza-bicyclo-[3.3.1]nonan-3-one.Acta crystallographica. Section E, Structure reports online · 2012Article
- High-affinity fluorescent ligands for the 5-HT(3) receptor.Bioorganic & medicinal chemistry letters · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
This report describes the synthesis and biological characterization of novel granisetron derivatives that are antagonists of the human serotonin (5-HT(3)A) receptor. Some of these substituted granisetron derivatives showed low nanomolar binding affinity and allowed the identification of positions on the granisetron core that might be used as attachment points for biophysical tags. A BODIPY fluorophore was appended to one such position and specifically bound to 5-HT(3)A receptors in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.