Trial reportPediatric pulmonology2010
Lessons learned from a randomized trial of airway secretion clearance techniques in cystic fibrosis.
Trial report in Pediatric pulmonology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Active cycle of breathing technique for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Oscillating devices for airway clearance in people with cystic fibrosis.The Cochrane database of systematic reviews · 2020Pooled it
- Oscillating devices for airway clearance in people with cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis.The Cochrane database of systematic reviews · 2015Pooled it
- Randomised cross-over trial evaluating the short-term effects of non-invasive ventilation as an adjunct to airway clearance techniques in adults with cystic fibrosis.BMJ open respiratory research · 2019Trial
- Trial
- A Longitudinal Study of Adherence among Cystic Fibrosis Patients: Associations with Gratitude Over the Course of One Year.International journal of behavioral medicine · 2025Article
- Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis.The Cochrane database of systematic reviews · 2023Review
- Investigating outcome measures for assessing airway clearance techniques in adults with cystic fibrosis: protocol of a single-centre randomised controlled crossover trial.BMJ open respiratory research · 2020Article
- Objective Versus Self-Reported Adherence to Airway Clearance Therapy in Cystic Fibrosis.Respiratory care · 2019Article
- A Comparison between Two Pathophysiologically Different yet Microbiologically Similar Lung Diseases: Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.International journal of respiratory and pulmonary medicine · 2018Article
- Personalising airway clearance in chronic lung disease.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Clinician's Commentary on Morgan et al.(1).Physiotherapy Canada. Physiotherapie Canada · 2015Article
- Effects of Autogenic Drainage on Sputum Recovery and Pulmonary Function in People with Cystic Fibrosis: A Systematic Review.Physiotherapy Canada. Physiotherapie Canada · 2015Article
- Eltgol acutelly improves airway clearance and reduces static pulmonary volumes in adult cystic fibrosis patients.Journal of physical therapy science · 2014Article
- Structure and function of the mucus clearance system of the lung.Cold Spring Harbor perspectives in medicine · 2013Review
- Short-term effects of high-frequency chest compression and positive expiratory pressure in patients with cystic fibrosis.Journal of clinical medicine research · 2011Article
- Parents as equal partners in the paediatric cystic fibrosis multidisciplinary team.Journal of the Royal Society of Medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
rationaleAirway secretion clearance therapies are a cornerstone of cystic fibrosis care, however longitudinal comparative studies are rare. Our objectives were to compare three therapies [postural drainage and percussion: (postural drainage), flutter device (FD), and high frequency chest wall oscillation: (vest)], by studying (1) change in pulmonary function; (2) time to need for intravenous (IV) antibiotics, (3) use of pulmonary therapies, (4) adherence to treatment, (5) treatment satisfaction, and (6) quality of life.
methodsParticipants were randomly assigned to one of three therapies twice daily. Clinical outcomes were assessed quarterly over 3 years.
resultsEnrollment goals were not met, and withdrawal rates were high, especially in postural drainage (51%) and FD (26%), compared to vest (9%), resulting in early termination. FEV(1) decline, time to need IV antibiotics, and other pulmonary therapies were not different. The annual FEF(25-75%) predicted rate of decline was greater in those using vest (P = 0.02). Adherence was not significantly different (P = 0.09). Overall treatment satisfaction was higher in vest and FD than in postural drainage (P < 0.05). Health-related quality of life was not different. The rate of FEV(1) decline was 1.23% predicted/year.
conclusionsThe study was ended early due to dropout and smaller than expected decline in FEV(1). Patients were more satisfied with vest and FD. The longitudinal decline in FEF(25-75%) was faster in vest; we found no other difference in lung function decline, taken together this warrants further study. The slow decline in FEV(1) illustrates the difficulty with FEV(1) decline as a clinical trial outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.