ArticleGenesis (New York, N.Y. : 2000)2010
Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancer.
Article in Genesis (New York, N.Y. : 2000), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Sall4 regulates downstream patterning genes during limb regeneration.Developmental biology · 2024Article
- Stepwise pluripotency transitions in mouse stem cells.EMBO reports · 2022Review
- Review
- Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells.Nature communications · 2020Article
- Down-regulation of CK2α correlates with decreased expression levels of DNA replication minichromosome maintenance protein complex (MCM) genes.Scientific reports · 2019Article
- Article
- Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells.Development (Cambridge, England) · 2017Article
- Wnt ligand presentation and reception: from the stem cell niche to tissue engineering.Open biology · 2017Review
- Monitoring Wnt/β-Catenin Signaling in Skin.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Transgenic flash mice for in vivo quantitative monitoring of canonical Wnt signaling to track hair follicle cycle dynamics.The Journal of investigative dermatology · 2014Article
- Wnt-signalling in the embryonic mammary gland.Journal of mammary gland biology and neoplasia · 2013Review
- Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube.PLoS genetics · 2013Article
- A new fluorescence-based reporter gene vector as a tool for analyzing and fishing cells with activated wnt signaling pathway.ISRN oncology · 2013Article
- The Wnt/β-catenin pathway regulates the expression of the miR-302 cluster in mouse ESCs and P19 cells.PloS one · 2013Article
- Investigating tonic Wnt signaling throughout the adult CNS and in the hippocampal neurogenic niche of BatGal and ins-TopGal mice.Cellular and molecular neurobiology · 2012Article
- Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.Cold Spring Harbor perspectives in biology · 2012Review
- Wnt signaling in mammalian development: lessons from mouse genetics.Cold Spring Harbor perspectives in biology · 2012Review
- Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.Nature communications · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We have characterized a transgenic mouse line in which enhanced green fluorescent protein (EGFP) is expressed under the control of multimerized LEF-1 responsive elements. In embryos, EGFP was detected in known sites of Wnt activation, including the primitive streak, mesoderm, neural tube, somites, heart, limb buds, mammary placodes, and whisker follicles. In vitro cultured transgenic embryonic fibroblasts upregulated EGFP expression in response to activation of Wnt signaling by GSK3beta inhibition. Mammary tumor cell lines derived from female LEF-EGFP transgenic mice treated with the carcinogen 7, 12-dimethylbenz[a]anthracene (DMBA) also express EGFP. Thus, this transgenic line is useful for ex vivo and in vitro studies of Wnt signaling in development and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.