Evidence map›Paper›PMID 20145800›Full record

ReviewPhysical chemistry chemical physics : PCCP2009

Simulation of DNA catenanes.

Alexander Vologodskii, Valentin V Rybenkov

Open access · greenAbstract readReview
In one paragraph

Review in Physical chemistry chemical physics : PCCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Alexander VologodskiiDepartment of Chemistry, New York University, 31 Washington Place, New York, NY 10003, USA. alex.vologodskii@nyu.edu
Valentin V Rybenkov
New York University · USUniversity of Oklahoma · US

Funding

DNA CATENANES AND TYPE II DNA TOPOISOMERASESR01GM054215 · NIGMS · NEW YORK UNIVERSITY · PI VOLOGODSKII, ALEXANDER V · 1996 to 2010
$2.8M
NIGMS NIH HHS R01 GM054215
6 · The paper itself

Abstract

DNA catenanes are important objects in biology, foremost as they appear during replication of circular DNA molecules. In this review we analyze how conformational properties of DNA catenanes can be studied by computer simulation. We consider classification of catenanes, their topological invariants and the methods of calculation of these invariants. We briefly analyze the DNA model and the simulation procedure used to sample the equilibrium conformational ensemble of catenanes with a particular topology. We consider how to avoid direct simulation of many DNA molecules when we need to account for the linking-unlinking process. The simulation methods and their comparisons with experiments are illustrated by some examples. We also describe an approach that allows simulating the steady state fraction of DNA catenanes created by type II topoisomerases.

Indexed as

Computer SimulationDNA, CatenatedDNA Topoisomerases, Type IIModels, MolecularNucleic Acid ConformationDNA, CatenatedDNA Topoisomerases, Type II

Identifiers

PMID20145800
PMCPMC2845312
OpenAlexW2170423701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.