ReviewJournal of biomedicine & biotechnology2010
Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.
Review in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Divergent roles of macrophage subsets, FoxP3, and IL-17A in HSV-1-induced CNS pathology.PLoS pathogens · 2025Article
- Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177-Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model.Molecular cancer therapeutics · 2022Article
- Review
- Plasmodium sporozoites induce regulatory macrophages.PLoS pathogens · 2020Article
- A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout.Parasite immunology · 2020Review
- Chinese liquor extract attenuates oxidative damage in HepG2 cells and extends lifespan ofFood science & nutrition · 2020Article
- Article
- Co-infection: the outcome of Plasmodium infection differs according to the time of pre-existing helminth infection.Parasitology research · 2018Article
- Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms.International journal of molecular sciences · 2017Review
- Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced byFrontiers in immunology · 2017Article
- Particles from the Echinococcus granulosus laminated layer inhibit IL-4 and growth factor-driven Akt phosphorylation and proliferative responses in macrophages.Scientific reports · 2016Article
- A prospective view of animal and human Fasciolosis.Parasite immunology · 2016Review
- Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.Frontiers in immunology · 2015Article
- Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Macrophage proliferation, provenance, and plasticity in macroparasite infection.Immunological reviews · 2014Review
- Helminths in the hygiene hypothesis: sooner or later?Clinical and experimental immunology · 2014Review
- An immunological marker of tolerance to infection in wild rodents.PLoS biology · 2014Article
- Helminth parasites alter protection against Plasmodium infection.BioMed research international · 2014Review
- The M1 and M2 paradigm of macrophage activation: time for reassessment.F1000prime reports · 2014Review
- M1 and M2 macrophages: the chicken and the egg of immunity.Journal of innate immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This review summarizes current knowledge of macrophages in helminth infections, with a focus not only on delineating the striking similarities in macrophage phenotype between diverse infections but also on highlighting the differences. Findings from many different labs illustrate that macrophages in helminth infection can act as anti-parasite effectors but can also act as powerful immune suppressors. The specific role for their alternative (Th2-mediated) activation in helminth killing or expulsion versus immune regulation remains to be determined. Meanwhile, the rapid growth in knowledge of alternatively activated macrophages will require an even more expansive view of their potential functions to include repair of host tissue and regulation of host metabolism.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.