ArticleBritish journal of cancer2010
Factors that contribute to faecal cyclooxygenase-2 mRNA expression in subjects with colorectal cancer.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Selection of optimal extraction and RT-PCR protocols for stool RNA detection of colorectal cancer associated immune genes.Scientific reports · 2024Article
- Decoding immune-related gene-signatures in colorectal neoplasia.Frontiers in immunology · 2024Article
- Review
- Potential prognostic and predictive value of UBE2N, IMPDH1, DYNC1LI1 and HRASLS2 in colorectal cancer stool specimens.Biomedical reports · 2023Article
- Identification of Six Genes as Diagnostic Markers for Colorectal Cancer Detection by Integrating Multiple Expression Profiles.Journal of oncology · 2022Article
- Multitarget Stool mRNA Test for Detecting Colorectal Cancer Lesions Including Advanced Adenomas.Cancers · 2021Article
- Integrin α6β4 in Colorectal Cancer: Expression, Regulation, Functional Alterations and Use as a Biomarker.Cancers · 2019Review
- Biological effects and clinical characteristics of microRNA-106a in human colorectal cancer.Oncology letters · 2017Article
- Droplet digital PCR for quantification ofWorld journal of gastroenterology · 2017Article
- Discovery of genes from feces correlated with colorectal cancer progression.Oncology letters · 2016Article
- Use of integrin alpha 6 transcripts in a stool mRNA assay for the detection of colorectal cancers at curable stages.Oncotarget · 2016Article
- Circulating and stool nucleic acid analysis for colorectal cancer diagnosis.World journal of gastroenterology · 2014Review
- Over-expression of COX-2 mRNA in colorectal cancer.BMC gastroenterology · 2014Article
- MicroRNAs: relevant tools for a colorectal surgeon?World journal of surgery · 2012Review
- Exosome can prevent RNase from degrading microRNA in feces.Journal of gastrointestinal oncology · 2011Article
- The expression and significance of feces cyclooxygensae-2 mRNA in colorectal cancer and colorectal adenomas.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously reported that a faecal cyclooxygenase-2 (COX-2) mRNA assay was useful for identifying colorectal cancer (CRC). This study sought to investigate the factors that contribute to faecal COX-2 mRNA expression in subjects with CRC.
methodsThe study cohort comprised 78 patients with CRC and 36 control subjects. The expressions of COX-2, beta-2-microglobulin (B2M), carcinoembryonic antigen (CEA), E-cadherin (E-cad), and CD45 mRNA in faeces and COX-2 mRNA expression in tissue were determined by quantitative real-time RT-PCR.
resultsThe level of faecal expression of COX-2 mRNA in CRC was significantly higher than that in controls. A significant correlation was found between faecal COX-2 mRNA expression and faecal B2M, CEA, E-cad, or CD45 mRNAs, markers of exfoliated total cells, colonocytes, and leukocytes, respectively. A significant correlation was found between the expression of COX-2 mRNA in faeces and tumour surface area, COX-2 mRNA expression in primary tumour. There was no difference in faecal COX-2 mRNA expression between proximal CRC and distal CRC.
conclusionCOX-2 mRNA expression in faeces seems to originate from tumour lesion and to be affected by factors such as the number of exfoliated cells, exfoliation of inflammatory cells, COX-2 mRNA expression in tumour, and tumour size.
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