SynthesisJournal of applied genetics2010
Association between alpha-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis.
Synthesis in Journal of applied genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women.Molecular biology reports · 2012Pooled it
- Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.International journal of colorectal disease · 2012Pooled it
- GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population.World journal of gastroenterology · 2011Pooled it
- Alpha-adducin Gly460Trp polymorphism and hypertension risk: a meta-analysis of 22 studies including 14303 cases and 15961 controls.PloS one · 2010Pooled it
- Diet-Microbiota-Host Interactions in Regulation of Cardiometabolic Homeostasis: Emerging Mechanisms and Therapeutic Potential.Microbiota and host · 2025Article
- Associations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Association Between Urinary Sodium and Potassium Excretion and Blood Pressure Among Non-Hypertensive Adults - China, 2018-2019.China CDC weekly · 2022Article
- Article
- Association between 24-h urinary sodium and potassium excretion and blood pressure among Chinese adults aged 18-69 years.Scientific reports · 2021Article
- Genetic Risk Factors of Intracranial Atherosclerosis.Current atherosclerosis reports · 2020Review
- Association of blood pressure with estimates of 24-h urinary sodium and potassium excretion from repeated single-spot urine samples.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- A Review of the Epidemiological Evidence for Adducin Family Gene Polymorphisms and Hypertension.Cardiology research and practice · 2019Review
- Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers.Clinical and experimental nephrology · 2017Article
- Habitual dietary intake of β-carotene, vitamin C, folate, or vitamin E may interact with single nucleotide polymorphisms on brachial-ankle pulse wave velocity in healthy adults.European journal of nutrition · 2016Article
- Genomics and Pharmacogenomics of Salt-sensitive Hypertension.Current hypertension reviews · 2015Review
- Genomics and pharmacogenomics of salt-sensitive hypertension Minireview.Current hypertension reviews · 2015Article
- The association of genetic variations with sensitivity of blood pressure to dietary salt: A narrative literature review.ARYA atherosclerosis · 2014Review
- Diagnostic tools for hypertension and salt sensitivity testing.Current opinion in nephrology and hypertension · 2013Review
- Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population.BioMed research international · 2013Article
- Genetics of salt-sensitive hypertension.Current hypertension reports · 2011Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linkage and association studies suggested the relationship between alpha-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. However, the currently available results were inconsistent. This study aimed to define quantitatively the association between salt-sensitivity and alpha-adducin Gly460Trp polymorphism in all published case-control studies. Publications from PubMed and other databases were retrieved. The major inclusion criteria were: (1) case-control design; (2) salt-sensitivity confirmed by sodium loading tests, and (3) the distribution of genotypes given in detail. Seven case-control studies fulfilled the inclusion criteria. In total they involved 820 subjects (454 salt-sensitive and 366 non-salt-sensitive). The meta-analysis shows that Gly460Trp polymorphism in general is not significantly associated with salt-sensitivity [OR (95%CI): 1.40 (0.96, 2.04), P = 0.08]. Subgroup analysis showed that the association is statistically significant in Asian people [OR (95%CI):1.33 (1.06, 1.69), P = 0.02] but not in Caucasian people [OR (95%CI):1.98 (0.57, 6.92), P = 0.28]. This indicates that blood pressure response to sodium varies between ethnical groups. More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension.
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