ArticleJournal of applied genetics2010
Transcriptomic signature of cell lines isolated from canine mammary adenocarcinoma metastases to lungs.
Article in Journal of applied genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Surgical Intervention and Treatment of a Mammary Adenocarcinoma in the Sugar Glider (Case reports in veterinary medicine · 2026Article
- Establishment and characterization of canine mammary tumors 622: A novel luminal B CMT cell line exhibiting partial epithelial-mesenchymal transition and intermediate drug sensitivity.Veterinary world · 2025Article
- Never a dull enzyme, RNA polymerase II.Transcription · 2023Review
- WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice.Cell biology and toxicology · 2023Article
- SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin.Cell death & disease · 2022Article
- Article
- WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway.Open life sciences · 2021Article
- Chemotherapy-Induced Extracellular Vesicle miRNAs Promote Breast Cancer Stemness by TargetingCancer research · 2019Article
- Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2.Structure (London, England : 1993) · 2017Article
- The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer.Molecules (Basel, Switzerland) · 2017Review
- The SPARC-related modular calcium binding protein 2 (Clinical ophthalmology (Auckland, N.Z.) · 2017Article
- Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage.Veterinary world · 2017Article
- Synergistic growth inhibitory effect of deracoxib with doxorubicin against a canine mammary tumor cell line, CMT-U27.The Journal of veterinary medical science · 2016Article
- In vitro comparative models for canine and human breast cancers.Clujul medical (1957) · 2016Review
- The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.Oncogene · 2015Article
- Genome-wide analysis of noncoding regulatory mutations in cancer.Nature genetics · 2014Article
- Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells.BMC veterinary research · 2013Article
- CSF-1R as an inhibitor of apoptosis and promoter of proliferation, migration and invasion of canine mammary cancer cells.BMC veterinary research · 2013Article
- Article
- Derivation of feline vaccine-associated fibrosarcoma cell line and its growth on chick embryo chorioallantoic membrane - a new in vivo model for veterinary oncological studies.Veterinary research communications · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis is a final step in the progression of mammary gland cancer, usually leading to death. Potentially, a molecular signature of metastasis can be defined via comparison of primary tumors with their metastases. Currently, there is no data in the literature regarding the molecular portrait of metastases in dogs and only few reports regarding human cancer. This is the first report describing the transcriptomic signature of canine cancer metastatic cells. Two adenocarcinoma cell lines isolated from the canine mammary gland (CMT-W1 and CMT-W2) were compared with cell lines isolated from their lung metastases (CMT-W1M and CMT-W2M) with regards to the following cytometric parameters: cell cycle, ploidy, Bcl-2 expression, susceptibility to induced apoptosis, and transcriptomic profile. Cytometric analyses revealed significant differences in cell cycle and antiapoptotic potential between the examined cells. Using oligonucleotide microarrays, we found 104 up-regulated genes in the metastatic cell line CMT-W1M and 21 up-regulated genes in the primary CMT-W1 cell line. We also found 83 up-regulated genes in the CMT-W2M cell line and only 21 up-regulated genes in the CMT-W2 cell line. Among the up-regulated genes in both metastatic cell lines, we found 15 common genes. These differently expressed genes are involved mainly in signal transduction, cell structure and motility, nucleic acid metabolism, developmental processing, and apoptosis (GHSR, RASSF1, ARF1GAP, WDR74, SMOC2, SFRP4, DIAPH1, FSCN1, ALX4, SNX15, PLD2, WNT7B, POU6F2, NKG7, and POLR2F). Seven of them are involved in a cellular pathway dependent on ghrelin via growth hormone secretagogue receptor (GHSR). Our results suggest that this pathway may be essential for mammary cancer cells to have a metastatic potential.
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