ArticleInfection and immunity2010
Examination of type IV pilus expression and pilus-associated phenotypes in Kingella kingae clinical isolates.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
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- Pathogenic determinants ofFrontiers in pediatrics · 2022Review
- Fulminant Infective Endocarditis Due toFrontiers in pediatrics · 2021Article
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- Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection.PLoS pathogens · 2019Article
- Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae.Infection and immunity · 2017Article
- In vitro characterization of biofilms formed by Kingella kingae.Molecular oral microbiology · 2017Article
- Kingella kingae Expresses Four Structurally Distinct Polysaccharide Capsules That Differ in Their Correlation with Invasive Disease.PLoS pathogens · 2016Article
- Kingella kingae: carriage, transmission, and disease.Clinical microbiology reviews · 2015Review
- RTX toxin plays a key role in Kingella kingae virulence in an infant rat model.Infection and immunity · 2014Article
- Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility.Journal of bacteriology · 2013Article
- Characterization of the Kingella kingae polysaccharide capsule and exopolysaccharide.PloS one · 2013Article
- Article
- Broad-spectrum biofilm inhibition by Kingella kingae exopolysaccharide.Journal of bacteriology · 2011Article
- Cytotoxic effects of Kingella kingae outer membrane vesicles on human cells.Microbial pathogenesisArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Kingella kingae is a gram-negative bacterium that is being recognized increasingly as a cause of septic arthritis and osteomyelitis in young children. Previous work established that K. kingae expresses type IV pili that mediate adherence to respiratory epithelial and synovial cells. PilA1 is the major pilus subunit in K. kingae type IV pili and is essential for pilus assembly. To develop a better understanding of the role of K. kingae type IV pili during colonization and invasive disease, we examined a collection of clinical isolates for pilus expression and in vitro adherence. In addition, in a subset of isolates we performed nucleotide sequencing to assess the level of conservation of PilA1. The majority of respiratory and nonendocarditis blood isolates were piliated, while the majority of joint fluid, bone, and endocarditis blood isolates were nonpiliated. The piliated isolates formed either spreading/corroding or nonspreading/noncorroding colonies and were uniformly adherent, while the nonpiliated isolates formed domed colonies and were nonadherent. PilA1 sequence varied significantly from strain to strain, resulting in substantial variability in antibody reactivity. These results suggest that type IV pili may confer a selective advantage on K. kingae early in infection and a selective disadvantage on K. kingae at later stages in the pathogenic process. We speculate that PilA1 is immunogenic during natural infection and undergoes antigenic variation to escape the immune response.
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Registered trials
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